Sehlahisoa sa lik'hemik'hale Bromazolam CAS 71368-80-4
Litaba tsa Motheo
Foromo ea molek'hule: C17H13BrN4
- Sebaka se qhibilihang: 272.0-275 ℃
- Sebaka se belang: 519.8±60.0 °C(Ho Boletsoe esale pele)
- boima ba 'mele: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40 (E boletsoeng esale pele)
- Foromo ea molek'hule: C17H13BrN4
- Boima ba 'mele: 353.21600
- 'Misa Hantle: 352.03200
- PSA: 43.07000
- Tlhaloso: 3.12480
Tšebeliso
Bromazolam e khetholloa e le buka ea benzodiazepine e qalileng ho etsoa ka 1976, empa ha e e-s'o ka e rekisoa.Ka mor'a moo e rekisitsoe e le lithethefatsi tse entsoeng ka moqapi, pele e tsejoa ka ho hlaka ke EMCDDA ea Sweden ka 2016. Ke bromo sebakeng sa chloro analogue ea alprazolam, 'me e na le liphello tse tšoanang tsa sedative le anxiolytic.Bromazolam e na le sebopeho se ts'oanang le li-benzodiazepines tsa setso, ho kenyelletsa alprazolam (ho nkela chlorine sebaka ka bromine) le bromazepam (keketso ea reng ea triazole).Alprazolam le bromazepam ke lintho tsa Schedule IV United States;bromazolam ha e reriloe ka ho hlaka.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine e sebelisetsoa ho ithuta mosebetsi oa ho thibela ho tšoenyeha, ho imeloa kelellong le psychotropics bakeng sa tsamaiso ea methapo e bohareng.
Mokhoa oa ho itokisa
Ba ile ba phekoloa ka pHLS9 (2 mg protheine /mL), 25 μg/mL Alamethicin (UGT reaction motsoako B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, le 0.6 mM ka 37° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase le 0.1 mM acetyl-CoA.Joale, 2.5 mM UDP-glucuronic acid (UGT reaction motsoako tharollo A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, le 50 μM clobromazolam kapa Bromazolam li ile tsa kenngoa.
Maemo a Maikutlo:50 μM Bromazolam bakeng sa metsotso e 360 ka 37°C
Lisebelisoa:Bromazolam metabolites e ne e letsebahatsoaka pHLS9 incubation.