Lithethefatsi tsa Lik'hemik'hale Lithethefatsi tse thusang CAS 59-46-1 PROCAINE
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Litaba tsa Motheo
Tlhaloso
Procaine ke sethethefatsi sa lehae se nang le tšebetso ea para-amino.Tlhokomeliso e ama haholo-holo litsebi tsa bongaka, tsa meno le tsa bongaka ba liphoofolo.
Lintho tsa Lik'hemik'hale
Letsoai la hydrochloride la 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 kapa N2C6H4COOCH2CH2NH(C2H5)2HCl) hangata le bitsoa procaine.Le hoja PABA ester e sa qhibilihe ka metsing, letsoai la hydrochloride le qhibiliha haholo metsing.
Lisebelisoa
1.Procaine (Novocain) e sebelisoa haholo-holo mekhoeng ea meno kapa ea bongaka e hlokang ho kenngoa ha anesthesia, peripheral block, kapa mokokotlo oa mokokotlo.
2.inhibitor ea mocha oa sodium
3. Procaine ke sodium channel blocker le inhibitor ea mekhoa e sa tšoaneng.
Tšebeliso
Tšebeliso ea ClinicalProcaine e hlahisoa ka potlako ho plasma ka li-cholinesterase le sebeteng ka ester hydrolysis ka pseudocholinesterase.The in vitroelimination half-life ke hoo e ka bang metsotsoana e 60.Boemo bofe kapa bofe bo fokotsang khatello ea cholinesterase bo ka eketsa ho pepeseha ha procaine le chefo e ka bang teng.Ts'ebetso e fokotsehileng ea enzyme e ka fumanoa ka khaello ea liphatsa tsa lefutso, lefu la sebete, bofokoli, khaello ea phepo e nepahetseng, ho hloleha ha renal, ho chesa, trimester ea boraro ea bokhachane, le ka mor'a ho etsoa opereishene ea pelo ea pelo.Ester hydrolysis e hlahisa PABA, e leng motsoako o ikarabellang bakeng sa karabelo e tloaelehileng ho theester anesthetics.Procaine ha e sebelisoe ka holim'a lihlooho ka lebaka la ho se khone ho feta ka har'a lipid membranes 'me e fumana tšebeliso e le moemeli oa ho kenya letsoho bakeng sa lera la letlalo kapa la mucous, mekhoa e khutšoanyane.Procaine e boetse e sebelisoa bakeng sa peripheral nerveblock le joalo ka epidural agent ho hlahloba matšoao a bohloko.