Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Isticmaalka caafimaadka
Toluene thiazide waxaa caadi ahaan loo isticmaalaa dawo dejineed, nasiyo muruq iyo xanuun.Badanaa waxaa loo isticmaalaa daawaynta teetanada.Xylazine waxay aad ugu egtahay daawooyinka sida phenothiazine, tricyclic antidepressants iyo clonidine.Sida daawada suuxinta, waxaa badanaa loo isticmaalaa marka lagu daro ketamiin.Xylazine waxay u muuqataa inay yarayso dareenka jidhka ee insulinta iyo qaadashada gulukooska.Yohimbine waa alfa2 adrenergic reseptor antagonist kaas oo loo isticmaalay in lagu yareeyo heerarka gulukooska ilaa heerar caafimaad qaba.Yohimbine wuxuu beddelaa waxyeelada soo raaca ee toluene thiazide ee goob bukaan-socod haddii xididka la siiyo wax yar ka dib marka toluene thiazide la maamulo.

farmashiyaha

Xylazine waa alfa 2 adrenergic agonist awood leh.Toluene thiazide iyo kuwa kale ee alfa2 adrenergic agonists ayaa loo qaybiyaa jidhka oo dhan 30-40 daqiiqo gudahood marka la bixiyo.Sababtoo ah lipophilicity sare, toluene thiazide waxay si toos ah u kicisaa reseptors α2 dhexe iyo sidoo kale xuubka αadrenergic ee unugyo kala duwan.agonist ahaan, toluene thiazide waxay keentaa hoos u dhaca neurotransmission ee norepinephrine iyo dopamine ee habka dhexe ee neerfayaasha.Waxay sidaas ku samaynaysaa iyada oo la jaanqaadaysa isku-xidhka norepinephrine ee autoreceptors ee dusha sare ee presynaptic, taas oo keenta jawaab celin celin ah norepinephrine.

Xylazine sidoo kale waxay u shaqeysaa sidii xannibaadaha gaadiidka iyadoo la joojinayo shaqada gaadiidka norepinephrine iyadoo si tartan ah u xannibaysa gaadiidka substrate-ka.Sidaa darteed, toluene thiazide ayaa si aad ah u kordhay K m mana saameynin V max.Tani waxay ku iman kartaa is dhexgalka tooska ah ee lala yeesho gobollada isku dhafka ah ee ka hortagga niyad-jabka.Tusaale ahaan, toluene thiazide iyo clonidine waxay joojiyaan qaadashada MIBG (analoogga norepinephrine) ee unugyada neuroblastoma.Xylazine waxay leedahay xiriiro kala duwan oo loogu talagalay cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, iyo soo-qabayaasha opioid.Qaab dhismeedkeeda kiimikaad waxa uu la mid yahay kuwa phenothiazines, tricyclic antidepressants iyo clonidine