Tesamorelin CAS: 804475-66-9 Unii-mqg94m5eeo Th 9507
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Isticmaalka
Tesamorelin (INN) (magaca ganacsiga Egrifta SV) waa nooc synthetic ee hormoonka koritaanka hormoonka sii daaya (GHRH) ee daaweynta lipodystrophy-xiriirka HIV-ga waxaana asal ahaan la ansixiyay 2010. Waxaa soo saaray oo soo saaray Theratechnologies, Inc. Canada.Daroogadu waa peptide synthetic oo ka kooban dhammaan 44 amino acids ee GHRH ee bini'aadamka iyadoo lagu daray kooxda trans-3-hexenoic acid.
Habka wax-qabadka
Tesamorelin waa N-terminus wax laga beddelay oo ku salaysan 44 amino acid isku xigxiga ee GHRH aadanaha.Qaabkan la beddelay ee synthetic waa ka waxtar badan yahay oo xasilloon marka loo eego peptides dabiiciga ah.Waxay kaloo adkeysi u leedahay kala-goynta dipeptide aminopeptidase marka loo eego GHRH aadanaha.Waxay kicisaa isku-darka GH-ga endogenous iyo sii-deynta waxayna kordhisaa heerarka koritaanka insulin-la mid ah (IGF-1).GH-ka la sii daayay wuxuu markaa ku xidhaa reseptors jooga xubnaha jirka ee kala duwan wuxuuna nidaamiyaa isku dhafka jirka.Xeerkan waxaa inta badan sabab u ah isku darka hababka anabolic iyo lipolysis.Si kastaba ha ahaatee, habka ugu muhiimsan ee loo helay tesamoline si loo yareeyo tirada dufanka jirka waa dhimista heerarka triglyceride ka dib lipolysis.