SARM SR9011 budada ceeriin ee daawada ee kor u qaadida adkaysiga jimicsiga CAS 1379686-30-2
SR9011 Faahfaahin degdeg ah
Cas No1379686-29-9
La mid ah 3-((((4-chlorobenzyl))((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Formula C23H31ClN4O3S
Miisaanka Molucelar 479.03524
SR9011Sharaxaada
SR9011 waa methacrylate monomer trifunctional kaas oo bixiya ku dhejinta khaaska ah ee birta
substrates.
SR9011 waxa lagu taliyay in loo isticmaalo dahaarka la daweeyay peroxide, shaabadeeyayaasha, iyo balaastiilada ku salaysan PVC.
Heerarka isticmaalka 5% ilaa 10% miisaan ahaan ayaa lagula talinayaa.
SR9011 waa mid awood leh oo gaar ah REV-ERB.Waxa kale oo ay ku fiican tahay soo-gaadhista maskaxda ee vivo.
Reseptors nukliyeerka REV-ERB-a iyo REV-ERB-β ayaa door muhiim ah ka ciyaara nidaaminta muujinta
borotiinada saacada xudunta u ah, waditaanka laxanka dhaqdhaqaaqa iyo dheef-shiid kiimikaadka.Maamulka SR9011 ayaa beddelaya
habdhaqanka circadian iyo qaabka circadian ee muujinta hiddo-wadaha saacada xudunta u ah hypothalami ee jiirarka.
Qaabka muujinta wareegga wareegga hiddo-wadaha dheef-shiid kiimikaadka ee beerka, muruqa lafaha iyo
unugyada adipose sidoo kale waa la bedelay, taasoo keentay kororka kharashka tamarta.Daawaynta cuntada ay keentay
Jiirarka buuran ee leh SR9011 waxay hoos u dhigeen cayilka iyagoo yareynaya tirada baruurta oo si muuqata u wanaajisay dyslipidemia iyo hyperglycaemia.Natiijooyinkani waxay muujinayaan in isku xidhka REV-ERB synthetic ee farmashiil ahaan bartilmaameedsado
laxanka wareegga ayaa laga yaabaa inuu faa'iido u leeyahay daaweynta cilladaha hurdada iyo sidoo kale cudurrada dheef-shiid kiimikaadka.
Sida loo isticmaalo SR9011?
In vitro: SR9011 waxaa loo adeegsaday 5-10 μM fiirsashada in vitro iyo baaritaanada gacanta.
In vivo: Maamulka IP ee SR9011 waxaa loo adeegsaday 100 mg/kg hal mar ama laba jeer maalintii 12-30
maalmo moodooyinka jiirka ee kala duwan.
Qalabaynta SR9009 iyo SR9011
| Shayga | Tilmaamid | Natiijo |
| Muuqashada | Budo aan ur lahayn, ku dhawaad cad ama cad | dhaaf |
| Aqoonsiga | Waqtiga haynta ee ugu sarreysa waa u xaqiiji RS | dhaaf |
| Khasaare xagga qalajinta | In aan ka badnayn 0.5% | 0.33% |
| Assay (HPLC) | Aan ka yarayn 99.0% | 99.59% |
| Hadhaaga dabka | In aan ka badnayn 0.1% | dhaaf |
| Bir culus | In aan ka badnayn 20 ppm | dhaaf |
Baakadaha & Bixinta
