Nimetazepam CAS: 2011-67-8 hypnotic tranquilizer

Nimetazepam waa jilitaanka dhexdhexaadka ah ee hypnotic, oo ka soo jeeda benzodiazepine.Waxaa markii ugu horreysay sameeyay 1964-kii koox Hoffmann-La Roche ah.Waxay leedahay hypnotic awood leh, ka-hortagga walaaca, dejin iyo saamaynta nasashada murqaha lafaha.Nimetazepam sidoo kale waa daaweye ka hortag ah oo waxtar leh oo gaar ah.Waxa loo iibiyaa sidii kaniini 5-miligram ah oo lagu magacaabo Erimin, waana magac calaamad ah oo ay samaysay Sumitomo oo ah shirkad weyn oo Japan ah.Japan waa dalka kaliya ee aduunka soo saara nimetazepam.Jaban ka baxsan, Erimin waxa laga heli karaa inta badan Bariga iyo Koonfur Bari Eeshiya waxaana si weyn loogu isticmaalaa daawaynta wakhtiga gaaban ee dadka hurdo la'aanta daran qaba ee ay ku adagtahay inay seexdaan ama hurdaan.Sumitomo waxay joojisay samaynta Erimin tan iyo Noofambar 2015. Wali waa la heli karaa si guud ama Lavol ah.

Nimetazepam waxaa si weyn loogu qoray 1980-meeyadii iyo 1990-meeyadii, gaar ahaan Japan, Malaysia, Brunei, Philippines, Thailand, Indonesia, Hong Kong iyo Singapore.Iyada oo xadgudubka iyo balwaduhu aad u bateen, daawadu aad bay hoos ugu dhacday tan iyo 2005. Waxa ugu horrayn loo isticmaalaa ka-hortagga xiska carruurta.Waxa kale oo weli loo isticmaalaa xaaladaha hurdo la'aanta ugu daran uguna daran ee goobaha bukaan-jiifka ama daawaynta bukaan-socodka ee muddada-gaaban.Ujeedadaas awgeed, kaniiniyada hurdada ee benzodiazepines Esazolam iyo nitrazepam ayaa loo isticmaalay si ka badan nitrazepam.Dawooyinka lidka diiqadda sida trazodone iyo mirtazapine ama Zopiclone iyo zolpidem ayaa ah dawooyinka safka koowaad ee hurdo la'aanta.

Inkasta oo rijeetada nimetazepam ay hoos u dhacday, ku xadgudubka daroogada ayaa weli ah mid sarreeya Brunei, Singapore, Malaysia iyo Filibiin.Waxaa caadi ahaan loo isticmaalaa marka lagu daro methamphetamine iyo ecstasy, iyo sidoo kale opioids (gaar ahaan heroin ama morphine).Nimetazepam waxaa saaran xayiraad sharciyeed oo adag gudaha Malaysia, taas oo ka dhigtay dawada gabaabsi, laakiin qaar badan oo ka mid ah kaniiniyada lagu iibiyo suuqa madow ee magaca Nimetazepam waa been abuur.Diazepam iyo nitrazepam waxay ka mid yihiin benzodiazepines inta badan laga isticmaalo gobolka, sidaas darteedna, badanaa waa la leexiyaa waxaana lagu iibiyaa suuqa madow, badanaa sida nitrazepam.

Soo saarista sharci darrada ah ee Nimezepam (oo loo iibgeeyo Erimin-5) ayaa ku baahsan gobolka.Xadgudubka nimetazepam ayaa sii kordhayey 2010-kii.Qabashada kiniinka Erimin-5 ee sida sharci-darrada ah loo soo saaray ayaa ku soo beegmay suuxdinta methamphetamine ee Malaysia.Tiro yar oo 46 kaniini ah oo Erimin-5 ah oo sharci darro ah oo la qabtay ayaa lagu tijaabiyay sifooyinkooda jireed iyo kiimikaad.Walaxda firfircoon, dopant, dareeraha aasaasiga ah, iyo dheeha ayaa ka kooban astaamaha kiimikada kiniinka.Natiijooyinku waxay muujiyeen in Nimetazepam uu ahaa walxaha ugu firfircoon ee ugu badan ee kiniinnada la qabtay.Lactose waxaa lagu ogaaday inuu yahay dareeraha ugu muhiimsan ee shaybaarada intooda badan, oo ay ku xigto mannitol ka dibna dicalcium phosphate dihydrate.Jaallaha qorrax dhaca ayaa laga helay inta badan shaybaarada kiniinka, oo keligii la isticmaalay ama lagu daray midabyo kale (tusaale tartar iyo Lichenol 4R) si kiniinka loo siiyo midib firisar/orange ah.Kiniinnada cagaarka ah ee muunada ku jira waxay ka koobnaayeen midabyo buluug iyo tartar dhalaalaya.Diazepam ugu horrayn waa daawada ka-hortagga werwerka waana walaxda firfircoon ee hal keliya oo ka mid ah 46-ka kiniin.Nitrazepam, oo ah dawo dejineed oo xoog leh iyo hypnotic iyo daawada waalidka ee nitrazepam, ayaa la ogaaday inay tahay xarun labaad, iyada oo kafeyntu ay tahay qaybta ugu muhiimsan ee lagu daray saddex kiniin.

Sannadkii 2003, Singapore waxay qabatay 94,200 oo kiniin ah Erimin-5.Shaybaadhka Xarunta Dhexe ee Maandooriyaha (CNB) ayaa tijaabooyin ku sameeyay kiniinka, natiijaduna waxay xaqiijisay inay runtii yihiin nitrazepam.