Clobetasol propionatewaxaa lagu daweyn karaa cudurka psoriasis.
La mid ah:
17-propionate;cgp9555;Clobetasol 17-propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propoion CLOBETASOL 17-PROPIONATE USP; -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;
Isticmaalka:
Clobetasol Propionatewaa qaabka cusbada propionate ee clobetasol, corticosteroid synthetic jirka oo leh anti-bararka, anti-pruritic, iyo sifooyinka vasoconstrictive.Clobetasol propionate waxay ku shaqeysaa saameynteeda iyadoo ku xireysa cytoplasmic glucocorticoid reseptors ka dibna waxay dhaqaajisaa soo-dhoweynta glucocorticoid ee dhexdhexaadinta muujinta hidda-wadaha.Tani waxay keenaysaa isku-darka borotiinnada ka-hortagga caabuqa qaarkood, iyadoo la joojinayo isku-dhafka dhexdhexaadiyeyaasha bararka qaarkood.Gaar ahaan, clobetasol propionate waxay u muuqataa inay kiciso phospholipase A2 borotiinada inhibitory ah, taas oo xakameynaysa sii deynta arachidonic acid horudhac barar ah oo ka yimaada phospholipids xuubka phospholipase A2.
Clobetasol propionate waa 17-O-propionate ester of clobetasol waxayna ka soo baxdaa clobetasol iyo propionic acid.Corticosteroid awood leh, waxaa loo isticmaalaa in lagu daweeyo xanuunnada maqaarka ee kala duwan, oo ay ku jiraan exzema iyo psoriasis.
Clobetasol propionate waxa la shatiyeeyay 1968 waxana ay soo gashay adeegsi caafimaad 1978. Waxa loo heli karaa dawo ahaan.Clobetasol propionate waxaa loo isticmaalaa daawaynta xanuunada maqaarka ee kala duwan oo ay ku jiraan canbaarta, labialis herpes, psoriasis, iyo lichen sclerosus.Waxa kale oo loo isticmaalaa in lagu daaweeyo cudurro dhowr ah oo difaaca jirka ah, oo ay ku jiraan alopecia areata, lichen planus (nodules maqaarka auto difaaca), iyo mycosis fungoides (T-cell skin lymphoma).Waxaa loo isticmaalaa sida daawaynta safka hore ee GVHD ba'an iyo dabadheeraad ah labadaba maqaarka. ama xanuunada hyperplastic.Waa corticosteroid-ka-soo-saarka fluorinated.Waxa laga yaabaa inay keento jawaab celin ka degdeg badan ama daba dheeraatay marka loo eego corticosteroids kale ee la mariyo.Waxaa lagu talinayaa in clobetasol ay haysato codsiga ugu badnaan 60 g/toddobaadkii wax aan ka badnayn 14 maalmood iyada oo aan la xidhin iyo in aan loo isticmaalin carruurta ka yar 12 sano.
Xalka betamethasone 21-methanesulfonate (4 g) ee dimethylformamide (25 ml) ayaa lagu daaweeyay lithium chloride (4 g) iyo isku dar ah ayaa lagu kululeeyay qubeyska uumiga 30 daqiiqo.Ku qasidda biyaha waxay siisay badeecada ceyriinka ah ee dib loo cusboonaysiiyay si ay u hesho dhismaha lahaanshaha, MP 226°C.
Clobetasol waxaa badanaa loo beddelaa propionate sida qaabka waxtarka leh ee falcelinta propionic anhydride.
Waqtiga boostada: Jan-05-2023