Hygromycin A CAS: 6379-56-2 Homomycin
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Guryaha Kiimikada:
budo cad.Asiidh daciif ah.Si xor ah ugu milmay biyaha iyo khamriga.Waxaa soo saaray Streptomyces hygroscopicus.
Adeegsada:
Hygromycin A, antibiyootiko la dayacay, ayaa si door ah u dila bakteeriyada keenta cudurka Lyme.Waxay awooday inay ku daweyso cudurka Lyme jiirarka iyada oo aan carqaladayn microbiome-ka.
Daawo (Antibiotics ballaaran).
Qeexid ChEBI: Alaab dabiici ah oo laga helay noocyada Streptomyces.
SR 9009 waa agonist REV-ERB synthetic kaas oo nidaamiya habdhaqanka wareegga iyo dheef-shiid kiimikaadka;waxay leedahay isticmaalka suurtogalka ah ee daaweynta hurdo la'aanta iyo cudurrada dheef-shiid kiimikaadka.Waa iskudhis sunta rasaasta ah oo loogu talagalay nooc cusub oo dawooyinka kansarka ah oo la xidhiidha saacadda wareegga jidhka.
SR9009, oo sidoo kale loo yaqaan Stenabolic, waa dawo cilmi baaris ah sida agonist ee REV-ERB.
REV-ERB-a iyo REV-ERB-β, laba soo-qabsayaal nukliyeer ah, ayaa door muhiim ah ku leh nidaaminta muujinta borotiinnada saacadaha udub-dhexaadka ah ee wadista laxanka dhaqdhaqaaqa iyo dheef-shiid kiimikaadka.
In vitro: SR9009 iyo analooga SR9011 labaduba waxay si ku-tiirsan u kordhin karaan waxqabadka cadaadiska REV-ERB-ku-tiirsan ee lagu qiimeeyay unugyada HEK293 oo muujinaya ximaeric Gal4 DNA binding domain: REV-ERB ligand binding domain α ama β iyo Gal4-jawaab leh luciferase wariye ah .Intaa waxaa dheer, SR9009 waxaa la ogaaday inuu awoodo inuu xakameeyo muujinta BMAL1 messenger RNA ee unugyada HepG2 ee habka REV-ERB-α/β-ku-tiirsanaanta.
In vivo: Jiirarka waxaa lagu daaweeyay hal qiyaas oo SR9009, SR9011 ama baabuur wakhtiga wareegga 6 (CT6 (6h ka dib nalalka) 12 maalmood ka dib xaaladaha D/D oo muujinaya muujinta ugu sarreysa ee Rev-erb-a. Natiijooyinku waxay muujiyeen in gaariga Irbadu ma keenin wax carqalad ah dhaqdhaqaaqa wareegga wareegga wareegga, taas bedelkeeda, maamulka hal dose oo ah SR9009 ama SR9011 ayaa horseeday luminta dhaqdhaqaaqa lugaha inta lagu jiro marxaladda mugdiga ah. iyada oo lagu nadiifinayo daawooyinka in ka yar 24 saac.
