Pharma Nadiifinta Sare API CAS14769-73-4 Hydrochloride Levamisole Base
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Macluumaadka aasaasiga ah
Qeexid
A 6-phenyl-2,3,5,6-tetrahydroimidazo [2,1-b] [1,3] thiazole oo leh qaabeynta S.Waxa loo isticmaalaa (guud ahaan sida cusbada monohydrochloride) si loogu daweeyo caabuqyada dirxiga ee doofaarka, idaha iyo lo'da waxaana hore loogu isticmaali jiray huma s sidii adjuvant chemotherapy ee daaweynta kansarrada kala duwan.Waxa kale oo si weyn loo isticmaalaa sida sinaysta kookaha.
Tilmaamaha
Levamisole (Ergamisol) waa daawada antiparasitic taas oo la ogaaday in ay xoojiso shaqada T-cell iyo difaaca gacanta.Daawadu waxay wanaajisaa badbaadada bukaanada qaba kansarka mindhicirka ee dib loo soo celiyay marka lagu daro 5-fluorouracil;habka isdhexgalkaan lama yaqaan.Levamisole ma laha firfircoonida antitumor ee ka dhanka ah kansarka asaasay ama metastatic mana loo helin waxtar u leh daawaynta adjuvant ee kansarada marka laga reebo kansarka mindhicirka.
Saamaynta xun ee ugu weyn ee levamisole waa lallabbo iyo anorexia.Finan maqaarka, cuncun, calaamadaha hargabka, iyo qandho ayaa sidoo kale la arkay.
Tilmaamaha
Levamisole (Ergamisol) waxaa markii hore loo soo saaray sidii daawo ka hortag ah.Waxay xoojisaa saamaynta kicinta ee antigens, mitogens, lymfokines, iyo arrimo chemotactic on lymphocytes, granulocytes, iyo macrophages.Waxaa la muujiyay inay kordhiso difaaca T-cell dhexdhexaad ah.
Levamisole si guul leh ayaa loogu isticmaalay daawaynta caabuqyada raaga.Waxa kale oo loo oggolaaday in lagu daro fluorouracil daaweynta kansarka mindhicirka.
Isticmaalka
Adeegsada Wax ka beddelka jawaabta noolaha.
Adeegsada Levamisole waxaa loo isticmaalaa xaaladaha hore iyo kuwa labaad ee difaaca jirka, cudurrada difaaca jirka, caabuqyada daba-dheeraada iyo kuwa soo noqnoqda, adenocarcinoma xiidmaha waaweyn, helmintosis, iyo rheumatoid arthritis.Ereyada la midka ah ee dawadan waa decaris, tetramizole, iyo kuwa kale.
Levimasole sidoo kale waa daroogada la doortay ee ascardiasis.Baaritaano badan ayaa muujinaya in hal dose oo levamisole ah uu ka bogsado 90 ilaa 100% bukaanada qaba ascardiasis, gaar ahaan kuwa qaba A. duodenale.Way yar tahay waxtarka ka hortagga ancylotomiasis iyo strongyloidiasis.Si kastaba ha ahaatee, waxtar uma laha N. americanus.Waxay u muuqataa inay u badan tahay inay saameyn gangliyostimulating ah ku leedahay unugyada dulinnada ee gobollada parasympathetic iyo naxariista labadaba.Waxaa intaa dheer, waxaa loo maleynayaa in daawadani ay saameyn immunomodulatory ah ku leedahay noolaha martida loo yahay.Ereyada la midka ah dawadan waa decaris, solacil, ergamisol, tramisol, immunol, iyo kuwa kale.
Isticmaalka Caafimaad
Ascariasis Hooworm infekshanka
Levamisole waxaa loo isticmaalay rheumatoid arthritis-ka iyo qaar ka mid ah xaaladaha kale ee la sheegay in ay ka jawaabaan waxqabadkeeda immunomodulatory.
Shaqada daawaynta
Kahortagga caabuqa
Dhaqdhaqaaqa ka hortagga jeermiska
Shaqadeeda ugu muhiimsan waa ka soo horjeeda Asc.lumbricoides iyo hookworms.Gooryaanku waa curyaan oo saxarada ku dhaafaan saacado yar gudahood.
Codsiyada Daawooyinka
L-isomer ee tetramisole, oo loo heli karo sida monohydrochloride.d-isomer ma laha wax qabad anthelmintic ah.Aad bay ugu milmay biyaha waxayna ku xasilloon tahay xaaladda qalalan.
Habka wax-qabadka
Levamisole wuxuu leeyahay firfircooni-immunomodulating.Waxaa la aaminsan yahay in ay nidaamiso hababka gacanta ee habka difaaca jirka, iyo habka ficilkiisa waxaa laga yaabaa inuu la xiriiro firfircoonida iyo koritaanka koritaanka T-lymphocytes, tirada korodhka monocytes iyo firfircoonida macrophages, iyo sidoo kale dhaqdhaqaaqa kordhay iyo hemotaxis ee neutrophylic. granulocytes.Levamisole sidoo kale wuxuu muujiyaa ficilka anthelmint.Waxay kaloo kordhisaa caabbinta guud ee jirka waxayna dib u soo celisaa shaqada T-lymphocyte iyo phagocyte oo beddelay.Waxa kale oo ay buuxin kartaa shaqada immunomodulatory iyadoo xoojisa falcelinta daciifka ah ee difaaca unugga, daciifinta falcelinta xooggan, oo aan wax saamayn ah ku yeelan falcelinta caadiga ah.