Glucagon CAS: 16941-32-5 Glucagon(1-29) Human HCl GLUCAGON 1-37

Glucagon, oo sidoo kale loo yaqaan hyperglycemin iyo glucagon, waa silsilad toosan oo hoormoon polypeptide ah oo ay soo daayaan unugyada α ee jasiiradda ganaca, oo ka kooban 29 amino acids.Qaaceeda molecular iyo miisaanka unugyadu qaraabo waa C153H225N43O49S=3482.8.Hormoonkaas waxa lagu soo saaray dalkayga.Budada crystalline cad ee heerkulka qolka, aan ur lahayn, dhadhamin.Aan ku milmin biyaha iyo inta badan dareerayaasha organic, ku milma aashitada iyo lye-ka-dilute.Inta badan diyaargarowga waxaa laga sameeyaa hydrochloride, kaas oo ku milma biyaha.Hadda waxaa la og yahay in glucagon ay ku qasban tahay in ay ilaaliso daacadnimadeeda molecular si ay u sameyso dhaqdhaqaaqeeda jireed.Qaab dhismeedka hyperglycemic wuxuu noqon karaa mid joogto ah bini'aadamka iyo naasleyda (bakaylaha, lo'da, doofaarka, jiirka, iwm.), laakiin wax yar ka duwan shimbiraha.Waa hoormoon muhiim ah si loo ilaaliyo sonkorta dhiigga caadiga ah.Shaqadeeda ugu weyn waa in ay kiciso fosfooraska myocardium, kor u qaadida kala-goynta glycogen oo ay yeelato saamaynta catecholamin-la mid ah.Sidaa darteed, waxay saameyn xooggan ku leedahay wadnaha wadnaha, kordhinta garaaca wadnaha, xanuunka myocardial iyo socodka dhiigga halbowlayaasha.Cardioenhancement kuma la socdaan kacsanaanta wadnaha oo kordhay, laakiin waxay kordhisaa ions calcium galay cardiomyocytes oo kicin kara adenosine cyclase on xuubka unugyada beerka ee Kiimikada Buugga, kor u synthesis of cyclic adenosine fosfateed ee unugyada.Glucagon ayaa lagu soo waramayaa inay waxtar u leedahay xaaladaha qaar ee wadno-gabka.Intaa waxaa dheer, heerarka balasmaha ayaa sidoo kale kor u kacay ilaa heerar kala duwan oo sonkorowga, cudurada beerka, cudurada kelyaha, burada glucagon iyo walbahaarka.Glucagon waxa uu leeyahay afar hawlood oo nafsiyeed oo kor u qaada glycogenolysis beerka, glycogenogenesis beerka, lipolysis iyo samaynta jidhka ketone.Waxay kor u qaadi kartaa qaadashada amino acids ee unugyada beerka, waxay dardargelisaa habka deamination ee asiidhyada amino acids ee beerka, waxay yaraynaysaa xoojinta asiidhyada amino ee plasma, waxay yareysaa isku-dhafka borotiinka waxayna kor u qaadaa glycogenogenesis beerka.Intaa waxaa dheer, waxay sidoo kale kicin kartaa awoodda lipase ee unugyada kaydinta dufanka beerka, waxay kordhisaa sii-deynta asiidhyada dufanka ee bilaashka ah, waxay kordhisaa habka oksaydhka lipoic acid ee unugyada beerka, waxayna kordhisaa wax soo saarka glycoconeogenesis beerka iyo ketone jirka.Isla mar ahaantaana, glucagon waxay joojin kartaa kacsanaanta iyo peristalsis ee caloosha, mindhicirka yar iyo mindhicirka, waxay yareysaa xiisadda xameetida, waxay joojisaa exocrine pancreatic, waxayna joojisaa nuugista biyaha iyo milixda ee xuubka xiidmaha.Qiyaaso badan oo glucagon ah ayaa sidoo kale kordhin kara xoojinta cAMP ee unugyada myocardial, kordhinta garaaca wadnaha iyo kor u qaadida xanuunka wadnaha