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Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide

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  • Magaca guud:Exendin-4
  • Lambarka CAS:141758-74-9
  • Qaaciidada molecular:C184H282N50O60S
  • Miisaanka molecular:4186.57188
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  • Faahfaahinta Alaabta

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    Email : salesperson66@yeah.net

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    wicker: cirfiid

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    Sifada:

    Magaca guud Exenatide Magaca Ingiriisiga Exenatide acetate cusbada
    Lambarka CAS 141758-74-9
    qaacidada molecular C184H282N50O60S
    Miisaanka molecular 4186.57000
    Tirada saxda ah 4184.03000
    PSA 1775.05000
    Xaaladaha kaydinta Xidhay, ku kaydi -20ºC
    Xasilooni Ma jiro burbur, lama yaqaan fal-celin khatar ah haddii la isticmaalo oo loo kaydiyo si waafaqsan tilmaamaha

     

    Isticmaalka:

    Exenatide waa daawada ugu horeysa ee fasalka cusub ee ka hortagga sokorowga ee loo yaqaan 'incretin mimetics', waxaana lagu tilmaamay inay tahay daaweyn dheeri ah si loo hagaajiyo xakameynta glycemic ee bukaanka qaba nooca 2aad ee sonkorowga kuwaas oo qaadanaya metformin, sulfonylurea, ama labadaba, laakiin aan lahayn la gaaray xakameyn ku filan glycemic.Exenatide waa analoog shaqaynaysa oo ah glucagon-like Peptide-1 (GLP-1).GLP-1 si dabiici ah ayaa looga sii daayaa unugyada ku jira marinka GI si ay uga jawaabto qaadashada cuntada waxayna ku shaqeysaa soo-dhoweynteeda unugyada b-unugyada si ay u kordhiso dheecaanka insulin-kicinta gulukooska.Exenatide waa agonist muddo dheer ku shaqeeya GLP-1 receptor.Waa nooc synthetic ah oo ah 39-amino acid peptide oo laga helo dheecaannada candhuufta ee lizard monster Gila.sidoo kale waxa ay dhexdhexaadisaa heerka ugu sarreeya ee glucagon-ka serum inta lagu jiro xilliyada hyperglycemic ka dib cuntada, laakiin ma faragelinayso sii deynta glucagon si ay uga jawaabto hypoglycemia.Habka qiyaasta ee exenatide waa 5 ama 10 mg laba jeer maalintii, oo loo maamulo sida cirbadeynta subcutaneous saacad gudaheed ka hor cuntada subaxda iyo fiidkii.Ka dib maamulka subcutaneous, uruurinta plasma ugu sarreysa ee exenatide ayaa lagu gaarey 2.1 saac, iyo astaanta farmashiyaha Plasma waa qiyaas ahaan.Dhacdooyinka xunxun ee ugu badan ee laga soo sheegay exenatide waxaa ka mid ah lallabbo, matag, shuban, dareemo gariir, dawakhaad, madax xanuun, iyo dyspepsia.

    Exendin-4 wuxuu dhaqaajin karaa soo-dhoweynta GLP-1, soo-dhoweeyuhu wuxuu kordhin karaa heerarka cAMP ee unugyada acinar ee ganaca gudaha gudaha, laakiin wax saameyn ah kuma laha soo-dhoweeyaha VIP.

    Exendin-4 waxaa loo isticmaalay sida incretin mimetics ee daawaynta unugyada HepG2 si looga saaro saamaynta walxaha kaaliyaha ah.Waxa kale oo loo isticmaalay sidii r (GLP-1R) agonist si looga saaro faragelinta walxaha caawiya.

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