Prostaglandins kiimikaad 99% nadiifinta API Material Lumigan Bimatoprost CAS 155206-00-1 ee daawaynta isha
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Isticmaalka
Bimatoprost waa daawada prostaglandin oo markii hore loo isticmaalay in lagu daweeyo cudurrada indhaha sida glaucoma.Magaca dawadu waa Lumigan.Si kastaba ha noqotee, inta lagu jiro koorsada daaweynta, bukaanku wuxuu si lama filaan ah u ogaaday in dhexroorka, dhererka iyo cufnaanta indhashareeraha uu si weyn u kordhay.Ka dib, bimatoprost ayaa loo isticmaalay tijaabooyinka kiliinikada ee quruxda indhaha.Saameynteeda weyn ee dhumucda iyo dhumucda indhashareeraha ayaa si toos ah u horseeday soo saarista Lattise ee shirkadda wax soo saarka Lumegen, Allergan.Daawadu waxa la bilaabay bishii Disembar 2008. Waxaa oggolaaday FDA-da Maraykanka, waxa ay noqotay wax soo saar xirfad leh oo madowga iyo adkaynta indho-shareeraha.
Bishii Luulyo 2006, dhibcaha indhaha ee bimatoprost-timolol maleate ee ay soo saartay United States Allergan Co., Ltd. waxaa ansixiyay maamulka dawooyinka EU si loo yareeyo jawaabta hal-isticmaalka β-receptor blockers ama prostaglandins.Cadaadiska intraocular ama hypertension indhaha ee bukaanada qaba glaucoma xagal furan oo aan si ku filan uga jawaabin daaweynta analoogga.Dhibcaha isha isku dhafan waxay ka kooban yihiin 0.0Chemicalbook3% bimatoprost iyo 0.5% timolol maleate, hal mar maalintii, waxay bixin kartaa kilin ahaan aad waxtar u leh xakamaynta cadaadiska indhaha, saameyntuna way ka fiican tahay tan bimatoprost oo keliya.Matoprost ama timolol maleate.Tijaabooyin caafimaad ayaa xaqiijiyay in daawadu ay leedahay dulqaad aad u wanaagsan, oo ay ku jirto hoos u dhac 40% ah ee dhacdooyinka hyperemia indhaha marka la barbar dhigo bimatoprost oo keliya.
Daawaynta glaucoma, waxa kale oo loo isticmaali karaa dareeraha koritaanka indhaha, fiirsashada waa 0.03%
Tilmaamaha
| Magaca Alaabta | Bimatoprost |
| CAS | 155206-00-1 |
| Cufnaanta | 1.1 ± 0.1 g/cm3 |
| Barta karkarinta | 629.8 ± 55.0 ° C at 760 mmHg |
| barta dhalaalaysa | 66-68 ° C |
| Molecular | C25H37NO4 |
| Miisaanka molecular | 415.566 |
| Barta toosan | 334.7 ± 31.5 ° C |
| Tayada Saxda ah | 415.272247 |
| PSA | 89.79000 |
| Logp | 1.98 |
| Muuqashada | Crystal Solid |
| Cadaadiska uumiga | 0.0 ± 1.9 mmHg at 25 ° C |
| Tilmaanta refractive | 1.591 |
| Xaaladaha kaydinta | 20 ° C |
Qaar ka mid ah Bimatoprost CAS 155206-00-1 Cilmi-baarista:
Olaparib wuxuu wax ku ool u ahaa Brca1;p53 burooyinka naaska (50mg/kg duritaan intraperitoneal maalintii), laakiin wax saamayn ah kuma yeelan Ecad-yarida HR; burooyinka naaska p53.Olaparib ma lahayn sun xaddidaysa qiyaasta jiirarka buro-sida.Olaparib ayaa loo isticmaalay in lagu daweeyo burooyinka leh isbeddellada BRCA, sida kansarka ugxan-sidaha, kansarka naasaha, iyo kansarka qanjirka 'prostate'.Intaa waxaa dheer, Olaparib ayaa si xushmad leh u hakiyay unugyada buro-yaraanta ATM-ka, taasoo soo jeedinaysa in Olaparib loo isticmaali karo wakiilka suurtagalka ah ee daaweynta burooyinka lymphoid-ka ee ATM-ku-beddelay.
Olaparib waa joojiyaha PARP kaas oo sidoo kale wax ka qabta BRCA1 ama BRCA2 isbeddellada.Olaparib wuxuu leeyahay saameyn yar oo ku saabsan tanky (polymer) enzyme-1, qiimaha IC50 wuu ka weyn yahay taas.Olaparib marka la uruuriyo 30-100nM wuxuu ku shaqeeyaa unugyada SW620 si uu u dhaqaajiyo PARP-1.Khadadka unugga BRCA1-deficient (MDA-MB-463 [1] iyo HCC1937) ayaa xasaasiyad u leh Olaparib marka la barbar dhigo BRCA1- iyo BRCA2 xariiqyada unugyada ku filan (Hs578T, MDA-MB-23,T47D) Olaparib wuxuu xannibaa PARP wuxuuna xannibaa dayactirka saldhigga , taasoo keentay dareenka xooggan ee unugyada KB2P ee Olaparib.Natiijadu waa u beddelashada nasasho hal-xadhigle ah oo loo beddelo nasasho laba-gees ah inta lagu jiro ku-noqoshada DNA-da, taas oo hawlgelinaysa dariiqa dib-u-habaynta ku-tiirsan ee BRCA2.
Bimatoprost waa prostamide F2a derivative, kaas oo si xushmad leh u ekaan kara saameynta prostamine ee lagu soo saaro jirka, kordhinta heerka wax soo saarka humor aqueous, yaraynta caabbinta qulqulka humor aqueous, iyo kordhinta kanaalka shabakada trabecular iyo uveal sclera Waxaa loo arkaa inay noqo daawada glaucoma-ka-hortagga ee deegaanka oo leh saameynta ugu xooggan ee dhimista cadaadiska indhaha.Waxay ku habboon tahay daawaynta glaucoma-furan (POAG) ama aragga sare ee aan waxtarka lahayn daawooyinka kale ee cadaadiska indhaha hoos u dhigaya.Bukaannada Dhiig-karka (OHT).
Xusay:
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