Alaabada kiimikada Bromazolam CAS 71368-80-4
Macluumaadka aasaasiga ah
Qaaciddada molecular: C17H13BrN4
- Meesha dhalaalka: 272.0-275 ℃
- Barta karkarinta: 519.8± 60.0 °C (La saadaaliyay)
- cufnaanta: 1.54± 0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37± 0.40 (La saadaaliyay)
- Qaacidada molecular: C17H13BrN4
- Miisaanka Molecular: 353.21600
- Tirada saxda ah: 352.03200
- PSA: 43.07000
- LogP: 3.12480
Isticmaalka
Bromazolam waxaa loo kala saaray inuu yahay benzodiazepine novel kaas oo markii ugu horeysay la sameeyay 1976, laakiin aan waligiis suuqgeyn.Ka dib waxaa loo iibiyey sidii daawo naqshadeeye ah, iyadoo markii ugu horreysay ay si rasmi ah u aqoonsatay EMCDDA ee Iswidhan 2016. Waa bromo halkii ay ka ahaan lahayd chloro analogue ee alprazolam, waxayna leedahay saameyn isku mid ah oo dejineed iyo anxiolytic.Bromazolam waxay qaab dhismeed ahaan la mid tahay benzodiazepines-dhaqameedka, oo ay ku jiraan alprazolam (oo ku beddelaya koloriinka bromine) iyo bromazepam (oo lagu daray giraanta triazole).Alprazolam iyo bromazepam waa walxaha Jadwalka IV ee Maraykanka;bromazolam si cad looma qorsheeyey.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine waxaa loo isticmaalaa in lagu barto dhaqdhaqaaqa ka-hortagga walaaca, antidepressant iyo psychotropics ee habka dhexe ee neerfayaasha.
Habka Diyaarinta
Waxaa lagu daweeyay pHLS9 (2 mg borotiin / ml), 25 μg/mL Alamethicin (UGT isku dhafka falcelinta B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, iyo 0.6 mM at 37 ° C NADP +, 0.9 U/ml isocitrate dehydrogenase, 100 U/mL superoxide dismutase iyo 0.1 mM acetyl-CoA.Kadib, 2.5 mM UDP-glucuronic acid (Xalka falcelinta UGT) 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, iyo 50 μM clobromazolam ama Bromazolam ayaa lagu daray.
Xaaladaha Falcelinta:50 μM Bromazolam 360min gudaha 37°C
Codsiyada:dheef-shiid kiimikaadka Bromazolam waxay ahaayeenla aqoonsadayee pHLS9 ku-dhufashada.