cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein gelatin Hydrolyzed

Sannadkii 1902-dii, Hermann Emil Fischer wuxuu ka go'doomiyay hydroxyproline ka samaysan jelatin hydrolyzed.Sanadkii 1905, Hermann Leuchs wuxuu sameeyay isku dhafka jinsiyadeed ee 4-hydroxyproline.

Hydroxyproline way ka duwan tahay proline marka ay joogaan kooxaha hydroxyl (OH) ee ku xiran atamka kaarboon gamma.

Hydroxyproline waxaa soo saara hydroxylation ee proline amino acid by prolyl hydroxylase ka dib isku-darka borotiinka.Dareen-celinta enzyme-catalyzed waxay ku dhacdaa gudaha lumen endoplasmic reticulum.Inkasta oo aan si toos ah loogu darin borotiinnada, hydroxyproline waxay ka kooban tahay 4 boqolkiiba dhammaan asiidhyada amino ee laga helo unugyada xayawaanka, in ka badan toddobada amino acids ee kale ee lagu daray.

collagen
Hydroxyproline waa qaybta ugu muhiimsan ee kolajka, taasoo ka dhigan qiyaastii 13.5% kolajka naasleyda.Hydroxyproline iyo proline waxay door muhiim ah ka ciyaaraan xasiloonida kolajka.Waxay u ogolaadaan spirals collagen inay si fiican u leexdaan.Kolajka caadiga ah ee XAa-Yaa-Gly triplet (halka Xaa iyo Yaa ay ka yihiin amino acid kasta), proline-ka haysta booska Yaa waa hydroxylated si loo soo saaro taxanaha XAa-hyp-Gly.Wax ka beddelka haraaga proline-ka waxay kordhisaa xasilloonida helix saddex jibbaaran ee kolajka.Waxaa markii hore la soo jeediyay in xasilloonidu ay sabab u tahay samaynta isku-xidhka isku xidhka hydrogen ee u dhexeeya kooxda prolyl hydroxyl iyo kooxda lafaha dhabarka ee carbonyl.Waxaa markaa ka dib la muujiyay in kororka xasilloonida ay inta badan tahay iyada oo loo marayo saameynta stereoelectronic, iyada oo fuuq-celinta haraaga hydroxyproline ay bixiso wax yar ama aan lahayn xasillooni dheeraad ah.