CAS: 152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

LVV-hemorphin-7 (LVV-h7) waa peptide bioactive ah oo ka dhashay hoos u dhaca silsiladda hemoglobin β-globin.LVV-h7 waa agonist gaar ah oo loogu talagalay soo-dhoweeyaha angiotensin IV.Soo dhaweeyuhu waxa iska leh fasalka aminopeptidase insulin-regulated (IRAP) waxana uu leeyahay firfircoonida oxytocin.Halkan, waxaan hiigsaneynaa inaan qiimeyno: i) haddii LVV-h7 ay wax ka beddesho habdhaqanka unugyada xoogga leh iyo jawaabta wadnaha ee cadaadiska, iyo ii) habka hoose ee saameynta LVV-h7 waxay ku lug leedahay firfircoonida soo-dhoweynta oxytocin (OT), taas oo noqon karta natiijada dhaqdhaqaaqa IRAP-proteolytic ee hoos u dhaca inta lagu jiro saacadaha dheeraadka ah.Jiirka Wistar ee qaangaarka ah (270 -- 370 g) ayaa helay (ip) LVV-h7 (153 nmol/kg) ama qaadaha (0.1 ml).Hab-maamuusyo kala duwan ayaa la isticmaalay: i) Goobta Furan (OP) ee tijaabinta hawlaha ciyaaraha/sahaminta;ii) Mazes Cross High (EPMs) ee dabeecadda walaaca;iii) Tijaabada dabaasha qasabka ah (FST) ee tijaabinta habdhaqanka niyad-jabka iyo iv) cirbada hawada ee jawaabta wadnaha iyo xididada soo-gaadhista walaaca ba'an.Diazepam (2 mg/kg) iyo imipramine (15 mg/kg) ayaa loo isticmaalay kontaroolo togan ee EPM iyo FST, siday u kala horreeyaan.OT receptor (OTr) antagonists atesiban (1 iyo 0.1 mg / kg) ayaa loo isticmaalay si loo go'aamiyo ku lug lahaanshaha dariiqa oxytocin.Waxaan ogaanay in LVV-h7: i) ay kordhisay tirada gelitaanka iyo wakhtiga lagu qaatay majaajilada gacmo furan, taas oo muujinaysa ka-hortagga walaaca;ii) Kicinta saamaynta antidepressant ee imtixaanada FS;iii) Sahminta iyo dhaqdhaqaaqa oo kordhay;iv) ma beddelin jawaabaha wadnaha iyo xididdada neuroendocrine ee diiqada ba'an.Intaa waxaa dheer, jimicsiga oo kordhay iyo saamaynta LVV-h7 ee ka hortagga niyad-jabka ayaa dib loo soo celiyay OTr antagonists.Waxaan ku soo gabagabeyneynaa in LVV-h7 ay wax ka beddesho dabeecadda ay muujisay qayb ka mid ah soo-dhoweeyaha oxytocin.