Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507
Ndibate
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Usage
Tesamorelin (INN) (zita rekutengeserana Egrifta SV) inzira yekugadzira yekukura kwehomoni inobudisa hormone (GHRH) yekurapa kweHIV-inobatanidza lipodystrophy uye yakatanga kubvumirwa muna 2010. Inobudiswa uye yakagadzirwa neTheratechnologies, Inc. Canada.Mushonga uyu ipeptide yakagadzirwa inoumbwa ne44 amino acids yemunhu GHRH pamwe nekuwedzera kweboka re trans-3-hexenoic acid.
Nzira yekuita
Tesamorelin iN-terminus yakagadziridzwa komisheni yakavakirwa pa44 amino acid sequence yeGHRH yevanhu.Iyi fomu yakagadziridzwa yekugadzira inoshanda uye yakagadzikana kupfuura peptides chaiyo.Iyo zvakare inopokana nekutsemuka nedipeptide aminopeptidase kupfuura GHRH yevanhu.Inokurudzira endogenous GH synthesis uye kusunungurwa uye inowedzera mazinga e insulin-sekukura chinhu (IGF-1).Iyo yakabudiswa GH inobva yasunga kune zvinogamuchirwa zviripo pamitezo yakasiyana-siyana yemuviri uye inogadzirisa kuumbwa kwemuviri.Uyu mutemo unonyanya kukonzerwa nekubatanidzwa kwevanabolic uye lipolysis nzira.Zvisinei, iyo nzira huru iyo tesamoline yakawanikwa kuderedza mafuta emuviri ndiyo kuderedzwa kwemazinga e triglyceride mushure me lipolysis.