Teduglutide CAS:197922-42-2 Teduglutide(ALX-0600) Revestive

Basa:
Teduglutide, inozivikanwa muchiRungu seTeduglutide, inofananidzira glucagon-yakafanana peptide 2 (GLP-2), homoni inowanzoitika inoderedza kubuda kwegastric uye secretion uye inogadzirisa kukura, kuwanda, uye kugadziriswa kwemaseru mudumbu remukati.Mushonga unowedzera nhamba yemasero aya, ayo anowedzera kunyura mudumbu duku uye kuderedza manyoka.
Kugadzirira:
Kuumbwa kwechimiro chemhete chine nhengo shanu kwakabatana zvakanyanya neiyo amino acid yeAsp kana Asn, uye Gly ndiyo inoumbwa nyore nyore ring dhizaini apo Gly inosanganiswa pamberi peAsp nekuda kwekushaikwa kweboka rekudzivirira uye yakaderera steric chipinganidzo parutivi. cheni.Nokudaro, hazvidzivisiki kuti kutevedzana kwekubatanidza nzira kuchaita kuti N-terminal amino acids yeTedulu Chemicalbook peptide iite mhete ine nhengo shanu mukugadzirisa, izvo zvinoderedza kuchena.Nokudaro, kuitira kugadzirisa dambudziko rekuparara kweAsp-Gly fragment, chidimbu chakachengetedzwa zvakakwana nechimiro chakaratidzwa muSEQIDNO: 2 yakatanga kugadzirwa nechidimbu chekubatanidza.Chimedu chakachengetedzwa zvizere chaive chekutanga ~ yechina amino acid yeN-terminal yetidulutide, kusanganisira iyo Asp-Gly chimiro, uyezve chidimbu chakachengetedzwa chakacheneswa.Iyo yakacheneswa zvizere chidimbu chakachengetedzwa chaive chakasimba-chikamu chakasanganiswa nechidimbu peptide resin ine chimiro chakaratidzwa muSEQIDNO:12, uye yekupedzisira cleavage yakaitwa kuti iwane tidurotide.