Somatostatin CAS: 51110-01-1 panhibin Anti-Somatostatin MUNHU, OVINE PORCINE RAT MOUSE 2ACOH 6H2O

Somatostatin, inozivikanwawo sekukura kwehomoni suppressor hormone (GHIH) kana mamwe mazita akawanda, inonzi peptide hormone inodzora endocrine system uye inokanganisa neurotransmission uye kuwedzera kwesero kuburikidza nekubatana neG-protein-coupled somatostatin receptors uye kudzivisa kusunungurwa kwemarudzi akasiyana-siyana. mahomoni.Secondary hormones.Somatostatin inhibits insulin uye glucagon secretion.

Somatostatin inouya mumhando mbiri dzinoshanda, dzinogadzirwa nealternating kucheka kweprogenin imwe chete: imwe ine 14 amino acids (inoratidzwa mubhokisi remashoko riri kurudyi), uye imwe inosanganisira 28 amino acids.

Mune vertebrates, kune matanhatu akasiyana somatostatin majini, anonzi SS1, SS2, SS3, SS4, SS5, uye SS6.Zebrafish dzine ese matanhatu.Majini matanhatu akasiyana, pamwe chete neshanu dzakasiyana somatostatin receptors, inopa somatostatin mabasa akasiyana siyana.Vanhu vane gene rimwe chete somatostatin, SST.

digestive system
Somatostatin inovanzwa ne delta masero munzvimbo dzakawanda mugayo system, dzinoti pyloric sinuses, duodenum, uye islets.

Somatostatin yakabudiswa ne pyloric sinuses inopinda mumoyo kuburikidza ne portal system uye inopinda mu systemic circulation kune nzvimbo yekudzivisa.Mukuwedzera, somatostatin yakasunungurwa ne δ masero anogona kushanda nenzira yeparacrine.

Mudumbu, somatostatin inoshanda zvakananga pamasero e-acid-inobudisa parietal kuburikidza neG-protein-coupled receptors (iyo inhibit adenylate cyclase uye nokudaro inonyatsopikisa histamine stimulation) kuderedza gastric acid secretion.Somatostatin inonyatso kudzikisa kugaya nekudzikisa zvisina kunanga kugadzirwa kweasidhi yemudumbu nekuvhara kuburitswa kwemamwe mahomoni akadai segastrin uye histamine.