SARM SR9011 Pharmaceutical Raw Powder Yekuwedzera Exercise Endurance CAS 1379686-30-2
SR9011 Quick Details
Cas No 1379686-29-9
Mazwi akafanana 3-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Formula C23H31ClN4O3S
Molucelar uremu 479.03524
SR9011Tsanangudzo
SR9011 ndeye trifunctional methacrylate monomer inopa yakasarudzika kunamatira kune simbi.
substrates.
SR9011 inokurudzirwa kuti ishandiswe muperoxide yakarapwa machira, sealants, uye PVC-based plastisols.
Kushandisa mazinga e5% kusvika ku10% nehuremu anokurudzirwa.
SR9011 ine simba uye chaiyo yakagadzirwa REV-ERB.Iyo ine zvakare yakanaka mu vivo plasma/brain exposure.
Manuclear receptors REV-ERB-α uye REV-ERB-β anoita basa rakakosha mukudzora kutaura.
yepakati wachi mapuroteni, kutyaira rhythms mukuita uye metabolism.Kutungamirirwa kweSR9011 anoshandura
circadian maitiro uye circadian pateni ye core wachi gene kutaura mu hypothalami yemakonzo.
Iyo circadian kutaura maitiro emhando dzakasiyana dzema metabolic genes muchiropa, skeletal tsandanyama uye
adipose tissue yakachinjwawo, zvichiita kuti simba riwedzere kushandiswa.Kurapa kwekudya-kunokonzerwa
obese mbeva ne SR9011 yakadzikira kufutisa nekudzikisa huwandu hwemafuta uye zvakanyanya kuvandudza dyslipidaemia uye hyperglycemia.Mhedzisiro iyi inoratidza kuti masynthetic REV-ERB ligands anonangwa nemishonga
iyo circadian rhythm inogona kubatsira mukurapa kwekusagadzikana kwekurara pamwe nezvirwere zvemetabolism.
Maitiro ekushandisa SR9011?
In vitro: SR9011 yakashandiswa pa 5-10 μM concentration mu vitro uye mumaserura assays.
In vivo: IP administration ye SR9011 yakashandiswa pa100 mg/kg kamwe kana kaviri pazuva nokuda kwe12-30.
mazuva mune akasiyana mbeva modhi.
Synthesis yeSR9009 uye SR9011
| Item | Tsanangudzo | Mhedzisiro |
| Chitarisiko | Hupfu husina kunhuwa hunenge huchena kana huchena | pass |
| Identificaton | Nguva yekuchengetedza yepamusoro pepamusoro ndeye simbisa kuRS | pass |
| Kurasika paKuomesa | Kwete kupfuura 0.5% | 0.33% |
| Assay(HPLC) | Kwete pasi pe99.0% | 99.59% |
| Ignition yasara | Kwete kupfuura 0.1% | pass |
| Simbi inorema | Kwete kupfuura 20 ppm | pass |
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