Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

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CAS NO:170713-75-4

Zita:Nociceptin

density1.47±0.1 g/cm3(Zvakafanotaurwa)

pka:3.19±0.10(Zvakafanotaurwa)

kuchengetedza temp.:−20°C

Chemical formula:C79H129N27O22

fomu:upfu

Molar mass:1809.04

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Nonoreceptor/orphenkephalin FQ (N/OFQ) inonzi 17-amino acid neuropeptide iyo iri endogenous ligand ye nonoreceptor (ORL-1).Nociceptive peptide, semushonga unoshanda weantianalgesic, unogona kunyatsogadzirisa mhedzisiro yemarwadzo.Kushandiswa kwaro kwakabatanidzwa nekushanda kwehuropi sekuona kurwadziwa uye kutya kudzidza.

Iyo genetic code ye prepronociceptin iri pamunhu Ch8p21.Pain sensitive peptides inotorwa kubva kune propain sensitive peptide mapuroteni, pamwe chete nemamwe mapeptide maviri, nocistatin uye NocII, ose ari maviri anodzivisa N / OFQ receptor basa.Nociceptin yaiva muenzaniso wekutanga we reverse pharmacology;Iyo NOP receptor yakawanikwa isati yawanikwa endogenous ligands nemapoka maviri akasiyana mu1995.

Muzvidzidzo zvemhuka, nzira yeN/OFQ-NOP yekugamuchira yakawanikwa ichitamba zvese zvakanaka uye zvisina kunaka mabasa mukudzidza nekurangarira.Semuenzaniso, kuputsika munzira iyi kwakabatanidzwa nekushandurwa kwekudzidza kwekutya mukusagadzikana kwehuropi senge post-traumatic stress disorder (PTSD).Nokudaro, nzira dzekugamuchira dzinochengetedza homeostasis mhinduro kune kutya uye kushungurudza mamiriro ezvinhu.Nociceptor inogonawo kuita inhibitory basa mukuyeuka basa, sezvimwe zvidzidzo zvakaratidza kuti zvinokanganisa kudzidza kwepakati mu vivo nekudzivisa kukurudzirwa kwenguva refu uye synaptic transmission in vitro.