Nimetazepam CAS: 2011-67-8 hypnotic tranquilizer

Nimetazepam ndeyepakati acting hypnotic, inotorwa benzodiazepine.Yakatanga kugadzirwa muna 1964 nechikwata cheHoffmann-La Roche.Iine simba rehypnotic, anti-kufunganya, kudzikamisa uye skeletal tsandanyama kuzorora mhedzisiro.Nimetazepam inonyanya kushanda anticonvulsant.Inotengeswa se5-milligram piritsi inonzi Erimin, zita rechiratidzo rakagadzirwa uye kutengeswa naSumitomo, kambani huru yekuJapan.Japan ndiyo chete nyika pasi rose inogadzira nimetazepam.Kunze kweJapan, Erimin inowanikwa munzvimbo dzakawanda dzekuMabvazuva neSoutheast Asia uye inoshandiswa zvakanyanya sekurapa kwenguva pfupi kune vanhu vane kushaya hope kwakanyanya vanowana zvakaoma kurara kana kurara.Sumitomo yakamira kugadzira Erimin kubva muna Mbudzi 2015. Ichiri kuwanikwa segeneric kana Lavol.

Nimetazepam yakatemerwa zvakanyanya muma1980 nema1990, kunyanya muJapan, Malaysia, Brunei, Philippines, Thailand, Indonesia, Hong Kong neSingapore.Nekushungurudzwa uye kupindwa muropa kwakapararira, zvirevo zvechirwere zvakawa zvakanyanya kubva 2005. Inoshandiswa zvakanyanya seanticonvulsant muvana.Izvo zvakare zvichiri kushandiswa mune zvakanyanya uye zvakanyanya uye zvinokanganisa zviitiko zvekushaya hope mune inpatient Settings kana yenguva pfupi kurapwa kwekunze.Nechinangwa ichi, mapiritsi ekukotsirisa benzodiazepines Esazolam uye nitrazepam aishandiswa kakawanda kupfuura nitrazepam.Antidepressants yakadai setrazodone uye mirtazapine kana Zopiclone uye zolpidem ndiyo mishonga yekutanga yekushaya hope.

Kunyangwe kunyorerwa kwenimetazepam kwadzikira, kushungurudzwa kwemushonga kunoramba kwakakwira muBrunei, Singapore, Malaysia nePhilippines.Inowanzoshandiswa pamwe chete nemethamphetamine uye ecstasy, pamwe chete neopioid (kunyanya heroin kana morphine).Nimetazepam iri pasi pezvirambidzo zvakasimba zvemutemo muMalaysia, izvo zvaita kuti mushonga ushomeke, asi akawanda emapiritsi anotengeswa pamusika mutema pasi pezita rekuti Nimetazepam ndeekunyepera.Diazepam nenitrazepam ndemamwe anonyanya kushandiswa benzodiazepines mudunhu, uye nekudaro, anowanzo kutsauswa uye kutengeswa pamusika mutema, kazhinji senitrazepam.

Kugadzirwa zvisiri pamutemo kweNimezepam (inotengeswa seErimin-5) kwakapararira mudunhu.Kushungurudzwa kwenimetazepam kwakaramba kuchiwedzera muma2010 ese.Kubatwa kwemapiritsi eErimin-5 akagadzirwa zvisiri pamutemo kwakabatana nekubatwa kwemethamphetamine muMalaysia.Nhamba diki yemapiritsi makumi mana nematanhatu eErimin-5 asiri pamutemo akabatwa akaedzwa kuti aone nezvemuviri nemakemikari.Iyo inoshanda musanganiswa, dopant, yekutanga diluent, uye dhayi zvinoumba chimiro chemakemikari pahwendefa.Mhedzisiro yacho yakaratidza kuti Nimetazepam ndiyo yainyanya kushandiswa musanganiswa muhuwandu hwemapiritsi akabatwa.Lactose yakaonekwa seyakanyanya diluent mumasampuli mazhinji, ichiteverwa nemannitol uyezve dicalcium phosphate dihydrate.Kuvira kwezuva kuyero kwakawanikwa mumasamples emapiritsi mazhinji, aishandiswa ari ega kana kuti akasanganiswa nemamwe madhayi (eg tartar neLichenol 4R) kupa piritsi repichisi/orenji.Mahwendefa egirinhi mumuenzaniso aive nemavara ebhuruu akajeka uye tartar.Diazepam inonyanya kushandisa mushonga wekurwisa kuzvidya mwoyo uye ndiyo inoshandiswa pahwendefa rimwe chete remapiritsi makumi mana nematanhatu.Nitrazepam, sedative ine simba uye hypnotic uye mubereki mushonga we nitrazepam, yakawanikwa iri yechipiri komboni, ine caffeine ichiva chinhu chikuru chakasanganiswa mumahwendefa matatu.

Muna 2003, Singapore yakabata mapiritsi eErimin-5 94,200.Rabhoritari yeCentral Narcotics Board (CNB) yakaita bvunzo pamapiritsi uye mhedzisiro yakasimbisa kuti zvechokwadi vaive nitrazepam.