Clobetasol propionate inogona kurapwa psoriasis?Zvese zvakajairika ganda zvirwere?

Clobetasol propionateinogona kurapwa psoriasis.

Mashoko anoreva zvakafanana:

17-propionate;cgp9555;Clobetasol 17-propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-dione; CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl) -9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate

Kushandisa:

Clobetasol Propionatendiyo propionate salt form of clobetasol, topical synthetic corticosteroid ine anti-inflammatory, anti-pruritic, uye vasoconstrictive properties.Clobetasol propionate inoita mhedzisiro yayo nekusunga kune cytoplasmic glucocorticoid receptors uye inozoita activate glucocorticoid receptor mediated gene expression.Izvi zvinoguma nekuumbwa kwemamwe mapuroteni anopesana nekuputika, nepo ichidzivisa kuumbwa kwevamwe varevereri vanopisa.Kunyanya, clobetasol propionate inoita seinoita kuti phospholipase A2 inhibitory mapuroteni, nokudaro ichidzora kusunungurwa kweanopisa precursor arachidonic acid kubva membrane phospholipids ne phospholipase A2.

Clobetasol propionate ndiyo 17-O-propionate ester yeclobetasol uye inotorwa kubva kuclobetasol uye propionic acid.Iyo ine simba corticosteroid, inoshandiswa kurapa akasiyana siyana eganda kusagadzikana, kusanganisira exzema uye psoriasis.
Clobetasol propionate yaive patented muna 1968 uye yakatanga kushandiswa mune zvekurapa muna 1978. Inowanikwa semushonga wegeneric.Clobetasol propionate inoshandiswa kurapa zvirwere zvakasiyana-siyana zveganda kusanganisira eczema, herpes labialis, psoriasis, uye lichen sclerosus.Inoshandiswawo kurapa akati wandei auto-immune zvirwere, kusanganisira alopecia areata, lichen planus (auto immune skin nodules), uye mycosis fungoides (T-cell skin lymphoma).Inoshandiswa seyekutanga kurapa kwezvose zvakakomba uye zvisingaperi GVHD yeganda.Clobetasol propionate (Cormax, Temovate, Embeline, Olux) ndeimwe yeakanyanya simba ezvishandiso zviripo iye zvino uye inoratidzwa kurapwa kwenguva pfupi kwekuzvimba. kana hyperplastic kusagadzikana.Iyo inogadzira fluorinated corticosteroid.Inogona kukonzera mhinduro yakakurumidza kana yakareba kupfuura mamwe topical corticosteroids.Zvinokurudzirwa kuti clobetasol ive nehuwandu hwekushandiswa kwe60 g / vhiki kwemazuva asingapfuuri 14 pasina kuvharwa uye kuti haifaniri kushandiswa muvana vari pasi pemakore gumi nemaviri.

Mushonga we betamethasone 21-methanesulfonate (4 g) mu dimethylformamide (25 ml) wakabatwa ne lithium chloride (4 g) uye musanganiswa wakapisa pamvura yekugezera kwemaminetsi makumi matatu.Dilution nemvura yakapa crude product iyo yakaitwa recrystalline kuti iwane iyo title compound, MP 226°C.
Clobetasol inowanzoshandurwa kune propionate seyakakosha fomu nekuita nepropionic anhydride.