NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

NPFF Neuropeptide (FLFQPQRFa) imhuka yemammalian aminated neuropeptide yakatanga yakatsaurwa kubva kuhuropi hwebovine uye inoonekwa sepeptide inodzora marwadzo ine antiopioid kuita kune morphine-induced analgesia.

Muvanhu, neuropeptide FF peptide yakavharidzirwa neNPFF gene.Majini maviri encoding maviri akasiyana receptors (NPFF1 uye NPFF2) uye maviri precursors (NPFFA neNPFFB) akaumbwa mumhuka dzinoverengeka.

Neuropeptide FF (NPFF) uye RFamide yakabatana peptides inobudiswa nevanotangira vaviri vanobatana nezvikamu zviviri zveG-protein-coupled receptors, NPFF1 uye NPFF2 subtypes, ine hukama hwakanaka uye inobatanidzwa mumabasa akasiyana-siyana ehupenyu, akadai sehutano hwemwoyo, hormone control, macrophage activation, thermohomeostasis, uye marwadzo regulation.

Kurapwa kweNPFFA precursor panzvimbo yekutanga proteolytic kunofanirwa kuburitsa peptide ine NPFF, iine matatu ekuwedzera N-terminal amino acids anosiyana kubva kumarudzi nemarudzi, uye peptide ine NPSF (SLAAPQRFa), iyo kureba kwayo kunoenderana nemhando.NPFFB yakaonekwa seyakatangira yeRFamide inoenderana peptide (RFRP, inozivikanwawo seGnIH yegonadotropin-suppressing hormone), ine peptides ine LPLRFa uye peptides inogovera yakafanana C-terminal PQRFamide motif seNPFF, yakadai seNPVF (VPNLPQRFa) munhu.

NPFF uye maopioid masisitimu akaratidzwa kupindirana pamatanho akawanda, kubva pahunhu hwemhuka kuenda kumamorekuru ekugamuchira.Nociception ndiyo inonyanya kudzidziswa physiological basa rekubatana uku, asi mubairo, kufamba, kudya uye kufamba kwematumbo kunokanganisawo.Endogenous opioid inodiwa kune analgesic properties yepinal injection yeNPFF, uye endogenous NPFF peptides inobatanidzwa mukugadzirisa kwekutsungirira kushivirira / hyperalgesia inokonzerwa nekusingaperi opioid therapy.

NPFF zvakare inodzora nhamba uye metabolism ye macrophages mune adipose tishu, izvo zvakakosha kune adipose tishu hutano.