Natural plant extracts CAS 51-34-3 Scopolamine
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Basic Information
Scopolamine(hyoscine) inowanikwa munhengo dzakasiyana-siyana dzeSolanaceae (semuenzaniso, H. niger, Duboisia myoporoides, Scopolia spp., uye Datura metel).Scopolamine kazhinji inoparadzaniswa kubva kudoro raamai rinosara kubva pakuparadzaniswa kwehyoscyamine.
Hyoscine izita rekare realkaloid iyi, kunyangwe scopolamine ndiro zita rinogamuchirwa muUnited States.Scopolamine inhengo yelevo yemusanganiswa weracemic inozivikanwa seatroscine.Iyo alkaloid inomisikidzwa zviri nyore mukuvapo kweiyo dilute alkali.
Iyo alkaloid inoitika muchimiro che levorotatory, viscousliquid inongonyungudika zvishoma mumvura asi yakanyanya solublein doro, chloroform, kana ether.Inoumba crystalline salts ine akawanda acids, ine hydrobromide iriyo yakagadzikana uye inonyanya kufarirwa inogamuchirwa.Mushonga wemvura wehydrobromide une 10% mannitol unonzi haunyanyi kuparara pane iwo usina kudzivirirwa.
Pharmacology
Scopolamine butylbromide, a modified scopolamine, iri peripheral anti-choline drug;haingogone kutsvedzerera tsandanyama spasm asiwo inovhara ganglion uye neuromuscular junction uye ine iyo isina simba mhedzisiro pakati.Mushonga uyu une simba rakasimba pamatumbo anotsvedzerera tsandanyama spasm pane atropine uye anisodamine;inogona kusarudza kubvisa gastrointestinal turakiti, biliary turakiti, uye weti turakiti inotsvedzerera tsandanyama spasm uye inhibit yayo peristalsis.
Scopolamine butylbromide ine mhedzisiro shoma pamwoyo, mudzidzi, uye salivary gland, saka haiwanzo kukonzeresa manyawi epakati, kuwedzera, inhibition yekubuda kwemate, uye mamwe maitiro asina kunaka, akasiyana neatropine.
Scopolamine butylbromide inopikisa M cholinergic receptor, maitiro ayo emishonga akafanana neatropine, asi ine maitiro ayo ane ruzivo rwakajeka mukuvandudza microcirculation yeropa.
Usage
1. Scopolamineinoshandiswa kune zvinenge zviratidzo zvakafanana neatropine, asi zvinofanira kuonekwa kuti ine sedative effect pamabasa emotokari, uye inokurudzirwa kurapwa kweParkinsonian zviratidzo.
2. cholinergic (ophthalmic).