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Manufacture Supply 99% Purity White Powder Antitumor Polypeptide Pharma Giredhi Kenza Tsvagiridzo MELITTIN CAS 20449-79-0

tsananguro pfupi:

Category: Toxic Substances

toxicity level: high toxicity

Kupisa kwengozi maitiro: kutsva, kunoparadza huturu hwenitrogen oxide gasi kana uchitsva

Kuchengetedza uye maitiro ekufambisa: dura tembiricha yakaderera, inofefetera, yakaoma;chengeta zvakasiyana kubva kune zvekudya zvekushandisa

Melittin, ine immune-inoenderana nePLA2-inokurudzira peptide kubva kuhuturu hwenyuchi, inowedzera basa repamusoro-molecular-uremu enzymes [1].Melittin i cytotoxic peptide inotorwa kubva muhuturu hwenyuchi.Melittin yakaratidza huturu kune ese A2780CR uye A2780 maseru, aine IC50 kukosha kwe4.5 uye 6.8 μg/mL, zvichiteerana.Melittin ine yakasikwa antibacterial, antiviral uye anti-inflammatory properties.Izvo zvakaratidzwawo kuve neakawanda anticancer mhedzisiro mune akati wandei akasiyana cancer maseru mitsara, kusanganisira gastric, zamu, ovarian, chiropa, prostate, cervical, uye kenza yemapapu maseru.Melittin, amphipathic hemolytic peptide, inoshandisa zvingangoita anticancer mhedzisiro kuburikidza nekudzivirirwa kwesero kuwanda, induction yeapoptosis, uye necrosis yakananga.


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Email:ceo66@hbainuodi.com

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MELITTIN CAS 20449-79-0

MELITTIN CAS 20449-79-0 Kushandisa:

Melitin ndiyo inonyanya kushanda muhuturu hwenyuchi.Beevenom imhando yehuturu hwakajeka hune hwema hwezvinonhuhwirira hunovanzwa nemushandi huturu hwenyuchi uye magland anowanikwa.Kana yatyorwa, inoburitswa parumborera.Pakati pezvinhu zvakawanda zvehuturu hwenyuchi, melittin ine yakanyanya kugutsikana, inoverengera inosvika makumi mashanu muzana yehuremu hwakaoma hwehuturu hwenyuchi, uye ine yakakwirira biological chiitiko.Melittin inonzi linear peptide inoumbwa ne 26 amino acids, ine huremu hwema molecular huremu hwe2849. Melittin ine high biological activity.Zvidzidzo zvemazuva ano zvemishonga zvakaratidza kuti ine anti-inflammatory, analgesic, inhibiting platelet aggregation, anti-AIDS uye mamwe akawanda maitiro.Melittin inogona kuburitsa simba rekuuraya rakasimba pane akasiyana masero masero kuburikidza nemaitiro akasiyana, uye inovimbisa kwazvo anti-tumor yemushonga wechisikigo.

Melittin inogona kutadzisa kukura uye kubereka kweanopfuura makumi maviri marudzi eGram-positive uye yakaipa mabhakitiriya, uye zvakare inogona kuwedzera antibacterial efficacy ye sulfonamides uye penicillins.Melittin inoparadza bhakitiriya cell membrane nekusunga kune membrane kuzadzisa chinangwa che bacteriolysis.Ose ari maviri melittin neayo matanhatu anobva kunze anogona kushandura mashandiro eT lymphocytes ane hutachiona hweHIV, kurambidza kudzokororwa kweHIV, uye kuderedza kutapukira kwehutachiona.

  1. Yakananga kuuraya mhedzisiro In vitro kuyedza yakasimbisa kuti melittin ine kuuraya kuri pachena kune akasiyana tumor cell mitsara senge osteosarcoma, ovarian cancer, uye glioma, uye kuuraya mhedzisiro inoenderana nedosi.Melittin inogona kuuraya bundu maseru uye kudzivirira kukura kwebundu maseru, uye haina mhedzisiro iri pachena pakukura kwemaseru akajairwa.Melittin inogona kuisa mukati memusero membrane yeK562 masero, kuumba pores, kukurudzira Ca2 + kupinda, kuwedzera kuwedzera kweCa2 + mumasero, kunokonzera sero lysis, uye kuuraya zvakananga masero eK562.Zvinowanzotendwa kuti melittin inonyungudutsa mitochondrial membrane yemasero, inhibits yakajairika kufema basa remamota maseru, inoparadza kugona kwavo kufema aerobic, inotadzisa kukura kwebundu tishu, uye inouraya zvakananga bundu maseru.
  2. Immunomodulatory effect Cellular immune system chinhu chakakosha chekudzivirira chemuviri kubva kumamota uye hutachiona hwehutachiona.Mamiriro emuviri wemasero ekudzivirira ekudzivirira anoita basa rakakosha mukuitika uye kukura kwemamota.Kuvandudza cellular immune function kunogona kutamba imwe anti-tumor athari.
  3. Induction yebundu cell apoptosis Apoptosis, inozivikanwawo seyakarongwa sero kufa, is a active cell biological process inodzorwa neakasiyana magene.Naizvozvo, apoptosis inzira inoshanda, iyo inosanganisira activation, kutaura uye kudzora kweakatevedzana ejeni.Zvidzidzo zvemazuva ano zvakaratidza kuti mishonga yakawanda yechemotherapeutic inogona kuzadzisa zvinangwa zvekurapa nekuita apoptosis mumasero egomarara.Kunyangwe kupinza apoptosis yave imwe yenzira yekuongorora anticancer mishonga.

Melittin inogona kuvharidzira basa re sPLA2 kubva kwakasiyana siyana, uye inhibition rate ye sPLA2 chiitiko mu synovial fluid yeRA varwere inogona kusvika 96%.Naizvozvo, kushandiswa kwe melittin kunogona kuderedza kukura kweRA.

Sub-dose melittin inogona kuderedza zvakanyanya iyo lysis mwero wekuzadzisa kumasero.Iyi nzira yekudzivirira inogona kunge yakabatana ne melittin inokurudzira Ca2 + kupinda, inokurudzira intracellular signal transduction system uye inodzivirira protein synthesis.Zvinokurudzirwa kuti kushandiswa kwehuwandu hwakakodzera hwe melittin kune humwe hutano hwehutano mukurapa RA ne Chemicalbook.Mumakore achangopfuura, zvidzidzo zvakaratidza kuti kuwanda kwakasiyana kwe melittin kunogona kukanganisa mashandiro esero kuburikidza nematanho akasiyana uye kuita zvakasiyana siyana biological mhedzisiro.Kushandiswa kwakakodzera kwe melittin kunopa mishonga mitsva yezvimwe zvirwere.

MELITTIN CAS 20449-79-0

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