Larazotide acetate CAS 881851-50-9
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Hunhu:
common name | Larazotide Acetate | Zita rechirungu | Larazotide acetate |
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CAS nhamba | 881851-50-9 | molecular uremu | 785.88500 |
molecular formula | C34H59N9O12 |
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misa yakarurama | 785.42800 |
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PSA | 360.55000 |
LogP | 3.73650 |
Kushandisa:
Larazotide acetate intestinal tight-junction regulator drug, yaimbozivikanwa seInnovate Biopharmaceuticals isati yabatanidzwa, iyo iri kuongororwa muvarwere vakuru vane chirwere chechiliac muchikamu chechitatu chekliniki yekuedza.Iyi single-chain peptide inotorwa kubva kumunhu zonulin, inozivikanwa modulator yeyakasimba junction permeability iyo yakasimudza intestinal tishu kutaura muvarwere vane chirwere chechiliac.LA inogoverawo maitiro akafanana neVibrio cholerae zonula occludens toxin (Zot), iyo inonzi enterotoxin iyo inovhiringidza intercellular tight junction structure kuburikidza ne actin polymerization uye cytoskeletal modifications iyo inoguma nekuwedzera intestinal permeability kuburikidza nechiratidzo che intracellular.Kunyange zvazvo LA yakaratidza kuvimbiswa mumakiriniki ekuedzwa kwevarwere vane chirwere chechiliac, zvidzidzo zvenguva pfupi zvinoshandisa mhando dzakasiyana-siyana dzekukuvara kwemhuka dzinoratidza kushandiswa kunogona kushandiswa kweLA kune zvimwe zvirwere nekuda kwekukwanisa kwayo kugadzirisa majoini akaoma.Iyi mini-ongororo ine chinangwa chekupa yakadzama sosi yeruzivo rwazvino pane iyi octapeptide.