GW-0742 SARMs Powder |GW610742 CAS 317318-84-6

tsananguro pfupi:

GW-0742
Chemical Name:[4--[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid
Mashoko anoreva zvakafanana:GW610742 kana GW0742
Nhamba yeCAS :317318-84-6
Chemical Formula:C21H17F4NO3S2
Molecular Weight:471.5
Kuchena:Kwete pasi pe99.0% (HPLC)
Chitarisiko:White crystalline yakasimba
GW0742 Melting Point:134.5- 135.5 °C
Kuchengeta:Chengetedza panzvimbo yekupisa, yakavharwa zvakasimba, kure nekupisa, chiedza uye unyoro.
Application:New SARM yakafanana neGW501516

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Usage

Kune kufutisa, chirwere cheshuga, dyslipidemia uye chirwere chemoyo Chirwere chekuyedza chaireva kudzora lipids uye kuwedzera mwero weHDL, kana cholesterol yakanaka, muropa.Sero-inogoneka, thiazolyl musanganiswa unoshanda seine simba, hukama hwepamusoro, PPARδ agonist.Inoratidza kusarudza kwePPARδ zvichienzaniswa nePPARα uye PPARγ.Haibudise chero chiitiko ichipokana nemamwe nyukireya kana asiri-nuclear receptors.Zvinonzi kuwedzera cholesterol efflux uye ABAC1 kutaura mune macrophages, fibroblasts, uye intestinal masero.

Cardarine inoshandiswa nevatambi vanokwikwidzana mumitambo yakasiyana-siyana.Semuenzaniso, vamhanyi vekutsungirira vanogona kuwedzera kutsungirira kwekurovedza muviri nekuisa iyi PPAR neAMP analog drug AICAR, kana kumhanya cardarine solo.Nekuda kweizvozvo, vanozove nekugona kukuru kusvika pakakwirira RPM panguva yekumhanya kwavo pasina kurova yakanyanya kurova kwemoyo.Izvi zvinobvumira mumhanyi / bhasikoro / kushambira kubiridzira chiyero chemoyo uye kuenda kureba pasina kuvhuvhuta, zvichiita kuti iyi stack chombo chinoshamisa chekushandisa mumitambo yekutsungirira.Chaizvoizvo, kubva pane zvakaitika kwandiri ndinogona kutaura kuti cardarine inogona kugogodza pamusoro pe30-45 masekondi kubva pane 5K nguva kana yakashandiswa kutungamirira kumujaho.

Tsanangudzo

MASHOKO ANOKOSHA:Kurasikirwa nemafuta, kunatsiridza kutsungirira, hapana mhedzisiro, muvaki wemuviri, kurapa kufutisa pamwe nekubatsira kuchengetedza kuonda, kunowedzera mhasuru.

Cardarine (GW-501516) yakabatanidzwa muchikamu cheSARMS, zvisinei mukugadzirisa uye tsanangudzo, iyo PPAR modulator.SePPAR modulator, inomutsa AMP-activated protein kinase uye inomutsa kutorwa kweglucose mu skeletal muscle tissue.GW-501516 ine hunyanzvi hwekudzoreredza matambudziko emetabolism nekukurudzira fatty acid oxidation.Inoonekwa sekurapa kwakasimba kwekufutisa uye mamwe mamiriro ane hukama.

GW501516 izita remushonga weGlaxo Wellcome (iyo GW inomirira kambani uye nhamba yacho ndeyechigadzirwa).Iyo inozivikanwa zvakare seGW-501,516, GW1516, GSK-516).Iyo PPARδ receptor agonist iyo isina kutorwa mberi kupfuura miedzo yekiriniki.Zvakadai zvinorambidzwa mumutambo.Inokodzera munzvimbo dzinoverengeka pane iyo rondedzero, kusanganisira chaizvo se "peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (semuenzaniso GW501516)".Asi zvakare yaizouya pasi pechikamu chitsva cheWADA chekubata zvese "zvisina kubvumidzwa zvinhu" izvo zvine chinangwa chekumisa chero mushonga usina rezinesi uri kushandiswa nevatambi.

GW501516 (inozivikanwawo seGW-501,516, GW1516, GSK-516) iPPAR & receptor agonist iyo yakagadzirwa mukubatana pakati peLigand Pharmaceuticals neGlaxoSmithKline muma1990s, yakapinda mukusimudzirwa kwekiriniki semumiriri wechirwere chechirwere chemoyo uye chirwere chemoyo. , uye yakasiyiwa muna 2007 nokuti kuongororwa kwemhuka kwakaratidza kuti mushonga wakaita kuti kenza iwedzere nokukurumidza munhengo dzakawanda.

Muna 2007 tsvakurudzo yakabudiswa ichiratidza kuti mazinga akakwirira eGW501516 akapiwa kumakonzo akavandudza maitiro avo emuviri;basa racho rakakurukurwa zvakanyanya munhau dzakakurumbira, uye zvakatungamirira kumusika mutema wemumiriri wezvinodhaka uye kushungurudzwa kwaro nevatambi seanorapa.

Applications

GW501516 inogona kushandiswa nevatambi se ergogenic performance enhancing drug iyo yakanga isati yava kudzorwa nemitemo kana kuonekwa nemiedzo yakajairika.Mumwe wevatsvagiri vakuru kubva muongororo yekuwedzera kutsungirira akagadzira bvunzo yeweti kuti aone mushonga, uye akaita kuti uwanikwe kuInternational Olympic Committee.

GW inokurudzira kutora glucose uye skeletal muscle tissue.Inopisa mafuta nekukurudzira fatty acid oxidation.Inokurudzirwa semushonga ungangoita wekufutisa nekuda kwekugona kwayo kunyungudutsa mafuta nekukurumidza.Uyewo, Cardarine inonzi inowedzera HDL nevhareji ye79% (yakanaka cholesterol) uye inoderedza LDL (yakaipa cholesterol) mune ikozvino Phase II miedzo.GW 501516 ndeye PPARδ agonist.Izvi zvinobatsira kuwedzera yako HDL mazinga kubva kune yakakwidziridzwa kutaura kweiyo cholesterol mutakuri ABCA1.