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Exendin-4 CAS 141758-74-9 Exenatide Acetate Munyu Exenatide

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  • Zita rakajairika:Exendin-4
  • Nhamba yeCAS:141758-74-9
  • Molecular formula:C184H282N50O60S
  • Molecular uremu:4186.57188
  • Package:Bhodhoro,Bag,Carton,Drum
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    Hunhu:

    Common name Exenatide Zita rechirungu Exenatide acetate munyu
    CAS nhamba 141758-74-9
    Molecular formula C184H282N50O60S
    Molecular uremu 4186.57000
    Misa yakarurama 4184.03000
    PSA 1775.05000
    Kuchengetedza mamiriro Yakavharwa, chengetedza pa -20ºC
    Kugadzikana Hapana kuora, hapana maitiro ane ngozi anozivikanwa kana akashandiswa uye akachengetwa zvinoenderana nezvinodiwa

     

    Kushandisa:

    Exenatide ndiyo yekutanga mushonga mukirasi nyowani yeanti-diabetes inozivikanwa se incretin mimetics, uye inoratidzwa seadjunctive therapy yekuvandudza glycemic control kune varwere vane Type 2 chirwere cheshuga vari kutora metformin, sulfonylurea, kana zvese zviri zviviri, asi vasina. akawana zvakakwana glycemic control.Exenatide inoshanda analog yemunhu incretin Glucagon-Senge Peptide-1 (GLP-1).GLP-1 inongoburitswa kubva mumasero ari muGI turakiti mukupindura kudyiwa kwechikafu uye inobata pane yayo receptor pa-b-masero kuti igone kuita glucose-inosimudzira insulin secretion.Exenatide inguva yakareba inobata agonist paGLP-1 receptor.Iyo ishanduro yakagadzirwa ye39-amino acid peptide inowanikwa mumate secretions eGila monster lizard.inogadzirisawo peak serum glucagon mazinga panguva dze hyperglycemic nguva dzinotevera kudya, asi hazvikanganise kuburitswa kweglucagon mukupindura hypoglycemia.Iyo dosing regimen ye exenatide ndeye 5 kana 10 mg kaviri zuva nezuva, inopihwa senge subcutaneous jekiseni mukati meawa pamberi pekudya kwemangwanani nemanheru.Kutevera subcutaneous administration, peak plasma concentrations of exenatide inosvika mumaawa 2.1, uye plasma pharmacokinetic profile inofananidzwa nedosi.Zviitiko zvinonyanya kuipa zvinoshumwa ne exenatide zvinosanganisira kusvotwa, kurutsa, manyoka, kunzwa jittery, dzungu, musoro, uye dyspepsia.

    Exendin-4 inogona kumisa iyo GLP-1 receptor, iyo receptor inogona kuwedzera cAMP mazinga epancreatic acinar masero mune intracellular, asi haina mhedzisiro paVIP receptor.

    Exendin-4 yakashandiswa se incretin mimetics yekurapa muHepG2 maseru kusabvisa pesvedzero yezvinhu zvekubatsira.Yakashandiswawo se r (GLP-1R) agonist kusabvisa kupindira kubva kune zvekubatsira zvinhu.

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