Stock API Raw Material Pharma Giredhi Yakakwirira Hunhu SR9011 CAS 1379686-29-9 Yekuvaka Muviri
Ndibate:
Email:ceo66@hbainuodi.com
Whatsapp/Skape:+8618849057872
Wickr:alice868
Usage
SR9011 iREV-ERBα/β agonist ine IC50s ye790 nM uye 560 nM yeREV-ERBα uye REV-ERBβ, zvichiteerana.Inogona kurapa gomarara.
Myocardial infarction ndechimwe chezvirwere zvakanyanya kufa kwezvirwere zvemoyo.Myocardial infarction inokonzerwa neconary artery stenosis kana spasm, zvichiita kuti acute kana kuramba anoramba ari myocardial ischemia uye hypoxia, uye myocardial cell kufa.Mhando dzakasiyana-siyana dzepro-inflammatory cytokines dzakadai se interleukin-1β (IL-1β) uye tumor necrosis factor-α (TNF-α) inobatanidzwa mukugadzirisa myocardial remodeling3.SR9011 iREV-ERBα/β agonist, nhengo yemhuri yenyukireya inogamuchira, uye zvidzidzo zvakawana kuti inogona kugadzirisa metabolism ye biological tissues.Huang Guodong akawana kuti SR9011 inoita basa rakakosha mukudzora rhythm yeautophagy genes muzebrafish.
C-terminus ye SR9011 family protein inoshaya ligand-binding domain, asi inogona kudzivisa kutaura kweRev-erb protein nekutsvaga nuclear receptor repressor factor uye histone deacetylase 3, etc. Histone deacetylase 3 iRev-erb agonist uye diki molecule kemikari probe.Fon-taine yakatanga kutaurwa muChemicalbook kuti pane kuwirirana pakati pe SR9011 nekuputika, uye SR9011 inogona kudzivisa kutaura kweTr4, nokudaro ichidzora chiratidzo chekuputika.Nyanzvi dzekune dzimwe nyika dzakaona kuti mune macrophages evanhu, kuwedzera mRNA kutaura kweSR9011 nemishonga yemishonga inotungamira zvakananga mukuderera kwemRNA kutaura kwepro-inflammatory factor interleukin-6.
Zvakafanana:
| 1-Pyrrolidinecarboxamide, 3-[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl- |
| SR9011 |
| UNII:VYI79FLZ6W |
| 3-({(4-Chlorobenzyl)[(5-nitro-2-thienyl)methyl]amino}methyl)-N-pentyl-1-pyrrolidinecarboxamide |
SR9011 CAS 1379686-29-9 Tsvagiridzo:
In vitro research:
SR9011 dose-inotsamira yakawedzera REV-ERB-inotsamira repressor basa uye RE4- Responsive luciferase reporter (REV-ERBα IC50 = 790 nM, REV-ERBβ IC50 = 560 nM).SR9011 zvine simba uye zvine hungwaru inodzvanya kunyoreswa mune co-transfection assay uchishandisa yakazara-yakareba REV-ERBα pamwe ne luciferase reporter gene inotungamirwa neBmal1 mutsigiri (SR9011 IC50 = 620nM).SR9011 inhibits BGAL1 mRNA kutaura muHepG2 masero mune REV-ERBα / β-inotsamira nzira [1] SR9011 inhibisa kuwanda kwekenza yemazamu cell mitsara pasinei neER kana HER2 yavo.SR9011 inoita seinomira kutenderera kwesero rekenza yemazamu pamberi pechikamu cheM.Cyclin A (CCNA2) yakaonekwa seyakananga gene yeREV-ERB, zvichiratidza kuti kudziviswa kwekutaura kwecyclin iyi neSR9011 kunogona kuyananisira kusungwa kwesero.Kurapa ne SR9011 kwakaguma nekuwedzera masero muG0/G1 chikamu uye kuderera kwemasero muS uye G2/M zvikamu, zvichiratidza kuti kushandiswa kweREV-ERB kunogona kukonzera kuderedzwa kushanduka kubva kuG1 kusvika kuS chikamu uye / kana S chikamu.
Physical research:
SR9011 yakaratidza kutaridzika kweplasma inonzwisisika, saka, kutaura kweREV-ERB majene anoteerera akaongororwa muzviropa zvemakonzo akabatwa nemhando dzakasiyana dzeSR9011 kwemazuva 6.Iyo plasminogen activator inhibitor type 1 gene (Serpine1) ndeye REV-ERB yakananga gene uye yakaratidza dhigirii-inotsamira kudzvinyirirwa kwekutaura mukupindura SR9011.Cholesterol 7α-hydroxylase (Cyp7a1) uye sterol inopindura chinhu chinosunga mapuroteni (Srepf1) majini akaratidzwawo kuti apindure kuREV-ERB uye akanga akadzivirirwa nedosi nekuwedzera kwehuwandu hweSR9011.Mushure memazuva e12 muD: D mamiriro, mbeva dzakaiswa jekiseni rimwechete re SR9011 kana motokari paCT6 (peak expression of Rev-erbα).Majekiseni emotokari haana kukonzera kukanganisa kwe circadian rhythmic locomotor chiitiko.Nekudaro, kutonga kwedosi rimwe chete reSR9011 kwakakonzera kurasikirwa kweiyo locomotor chiitiko panguva yerima yezvidzidzo.Kuita kwakajairika kunodzokera kune inotevera circadian cycle, inopindirana nekubvumidzwa kwezvinodhaka kweasingasviki maawa makumi maviri nemana.Pasi pemamiriro erima anogara aripo, iyo SR9011-inotsamira kuderedzwa kwegumbo kumhanya hunhu mumakonzo kwaienderana nedosi, uye potency (ED50 = 56 mg/kg) yakanga yakafanana neyeiyo SR9011-mediated inhibition yeREV-ERB mhinduro gene, Srebf1. , in vivo (ED50 = 67mg/kg) [1].