CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7
Usage
LVV-hemorphin-7 (LVV-h7) inonzi bioactive peptide inokonzerwa nekuora kwehemoglobin β-globin chain.LVV-h7 inonzi agonist chaiyo yeangiotensin IV receptor.Iyi receptor ndeye insulin-regulated aminopeptidase (IRAP) kirasi uye ine oxytocin chiitiko.Pano, isu tine chinangwa chekuongorora: i) kana LVV-h7 inoshandura maitiro ezvinyoro zvakadzika uye mhinduro yemwoyo kune kushungurudzika, uye ii) iyo nzira yeLVV-h7 migumisiro inosanganisira kushandiswa kweoxytocin (OT) receptor, iyo inogona kuva iyo. mhedzisiro yekuderedzwa kweIRAP proteolytic chiitiko panguva yakawandisa.Murume mukuru Wistar rats (270 -- 370 g) akagamuchira (ip) LVV-h7 (153 nmol/kg) kana mutakuri (0.1 ml).Mitemo yakasiyana-siyana yakashandiswa: i) Open Field (OP) kuedza kwemitambo / kuongorora mabasa;ii) Elevated Cross mazes (EPMs) yekushushikana-semaitiro;iii) Kumanikidzirwa kushambira bvunzo (FST) bvunzo yekuora mwoyo-kunge maitiro uye iv) jekiseni remhepo remoyo kupindura kune acute kusagadzikana.Diazepam (2 mg / kg) uye imipramine (15 mg / kg) yakashandiswa sekutonga kwakanaka kweEPM neFST, maererano.OT receptor (OTr) vanopikisa atosiban (1 uye 0.1 mg / kg) vakashandiswa kuona kubatanidzwa kweoxytocin nzira.Takaona kuti LVV-h7: i) yakawedzera nhamba yekupinda uye nguva yakashandiswa mumaze nemaoko akazaruka, iyo yakaratidza kupesana-kuzvidya mwoyo;ii) Kukurudzira antidepressant mhedzisiro muFS bvunzo;iii) Kuwedzera kuongorora uye kufamba;iv) haina kuchinja mhinduro dzemoyo uye neuroendocrine kune zvakanyanya kushushikana.Mukuwedzera, kuwedzera kwekurovedza muviri uye LVV-h7 yakakonzera antidepressant migumisiro yakadzorerwa neOTr vanopikisa.Tinogumisa kuti LVV-h7 inogadzirisa maitiro anoratidzwa muchikamu neoxytocin receptor.
