C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-α-aspartylglycylglycyl-

C-terminal peptide (CTX), inozivikanwawo secarboxy-terminal collagen crosslinking, iC-terminal peptide yefibrous collagens senge Type I uye Type II.Inoshandiswa sebiomarker muserum kuyera kuchinja kwemapfupa.Inogona kushandiswa kubatsira varapi kuti vaone mhinduro yemurwere pakurapwa kusina kuvhiyiwa, pamwe nekuongorora dambudziko remurwere rematambudziko panguva yekuporesa mushure mekupindira kwekuvhiya.[1] Muedzo weCTX mamaki, anonzi Serum CrossLaps, akanyanya kutarisisa bhonzo resorption kupfuura chero imwe bvunzo iripo parizvino.

Mukutanga kwe2000s, chibatanidzo chakaonekwa pakati pekushandiswa kwebisphosphonate uye kukuvara kwemuviri kumapfupa.Kudzivirirwa kwakasimba kwe osteoclast basa ne bisphosphonate therapy kunogona kukonzera kudzvinyirirwa kwemaitiro ekugadzirisa mapfupa, zvichiita kuti kukanganiswa kwemaronda kupora mushure mekutambudzika (zvakadai sekuvhiyiwa kwemazino), uye kunyange kungoerekana kusina kuporesa pfupa.Nemhaka yokuti bisphosphonate inonyanya kuiswa mumapfupa ane kuchinja kwakawanda, bisphosphonate mazinga mushaya anogona kunge akasarudzwa akakwirira.

Nekuuya kwekuiswa kwemazino, nhamba iri kuwedzera yevarwere vemazino vari kurapwa kunosanganisira kuporesa kwepfupa mumuromo, zvakadai sekuvhiyiwa kwekudyara uye mapfupa emapfupa.Kuti aongorore njodzi ye osteonecrosis muvarwere vanotora bisphosphonates, Rosen akaunza CTX biomarker mu2000.