SARM SR9011 Pharmaceutical Raw Powder Mo Faʻateleina le Faʻamalositino Tumau CAS 1379686-30-2

SARM SR9011 Pharmaceutical Raw Powder Mo Faʻamalosia le Faʻamalositino Tumau CAS 1379686-30-2 Ata Faʻaalia

fa'amatalaga puupuu:

Fa'amatalaga Fa'amatalaga Fa'amatalaga

Igoa o oloa:SR9011
Oloa Fa'atatau:SR9009
CAS:1379686-29-9
Fa'aaliga:Pa'u Pa'epa'e
Fa'aoga:Fausia Musele
Auala va'a:EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Malamalama maualuga:sarms fa'aopoopo fau tino, sarms steroids

Auina imeli ia matou

Fa'amatalaga Oloa

Faailoga o oloa

SR9011 Fa'amatalaga vave

Cas Numera 1379686-29-9
Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Fuafua C23H31ClN4O3S
Molucelar mamafa 479.03524

SR9011Fa'amatalaga

O le SR9011 o se monomer methacrylate fa'apitoa e maua ai le pipii fa'apitoa i u'amea
mea'ai.

SR9011 ua fautuaina mo le faʻaaogaina i faʻamaʻi faʻamalolo faʻamalolo, faʻamaufaʻailoga, ma plastisols faʻavae PVC.
Fa'aaoga tulaga o le 5% i le 10% i le mamafa e fautuaina.

O le SR9011 o se REV-ERB malosi ma fa'apitoa.E lelei fo'i i vivo plasma/fai'ai fa'aalia.
O le faʻaogaina faaniukilia REV-ERB-α ma REV-ERB-β o loʻo i ai se sao taua i le faʻatonutonuina o faʻamatalaga.
o polotini autu o le uati, ave le pao i gaioiga ma metabolism.Pulega o le SR9011 suia
amio circadian ma le mamanu circadian o le fa'aaliga autu o le uati i le hypothalami o isumu.
O le fa'ata'ita'iga fa'asologa o le fa'asologa o kenera metabolic i le ate, musele skeletal ma
ua toe suia foi aano o le tino, ma i'u ai i le faateleina o tupe faaalu.Togafitiga o mea taumafa
isumu lapo'a ma le SR9011 fa'aitiitia le puta e ala i le fa'aitiitia o le ga'o ma fa'aleleia lelei le dyslipidemia ma le hyperglycaemia.O nei fa'ai'uga o lo'o fa'ailoa mai ai le fa'aogaina ole REV-ERB ligand e fa'atatau ile vaila'au
e mafai ona aoga le pa'u o le circadian i le togafitia o faaletonu o le moe faapea foi ma gasegase metabolic.

Fa'afefea ona fa'aoga SR9011?

In vitro: SR9011 na faʻaaogaina i le 5-10 μM faʻatonuga i vitro ma i suʻega feaveaʻi.
In vivo: IP pulega o le SR9011 na faʻaaogaina i le 100 mg / kg tasi pe faalua i le aso mo le 12-30
aso i fa'ata'ita'iga isumu eseese.

Fa'asologa o le SR9009 ma le SR9011

O mea faʻapipiʻi na faʻapipiʻiina e ala i le faʻaitiitia o le amination o le 5-nitro-2-thiophenecarboxaldehyde ma le 4-chlorobenzylamine ma le sodium triacetoxyborohydride na maua ai le amine lona lua.O se amination faʻaititia lona lua ma le 1-Boc-pyrrolidine-3-carboxaldehyde na maua ai le amine maualuga.O lenei vailaʻau na togafitia i le trifluoroacetic acid e aveese ai le Boc-protecting group, ona tali atu lea i le ethyl chloroformate (SR9009) poʻo le pentyl isocyanate (SR9011) e tuʻuina atu ai oloa manaʻomia.

SR9011COA

Aitema	Fa'amatalaga	I'uga
Fa'aaliga	O se pauta e leai se manogi, toetoe lava pa'epa'e pe pa'epa'e	pasi
Fa'ailoaga	Ole taimi ole taofi ole tumutumu tele ole fa'amaonia i le RS	pasi
Ma'imau ile Fa'amago	E le sili atu i le 0.5%	0.33%
Su'ega(HPLC)	Le itiiti ifo i le 99.0%	99.59%
Toega mumu	E le sili atu i le 0.1%	pasi
Uamea mamafa	Le sili atu i le 20 ppm	pasi