Gaosi oloa Dihexa CAS 1401708-83-5
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Fa'aoga:
DIHEXA (PNB-0408), o se oligoplase reagent, o se IV analog o vascular tensionin IV faatasi ai ma le tautala tautala ma le toto-faiai pa permeability.Dihexa maualuga-faauo ma le malosi tuʻufaʻatasia le vaega tuputupu aʻe o le hepatocyte (HGF), ChemicalBookkd tau o le 65PM, ma faʻaleleia lana gaioiga i le taliaina C-MET.O lo'o fa'aalia e le Dihexa le lelei tele o le anti-ejaculation ma fa'aleleia galuega fa'atino i fa'ata'ita'iga manu.Dihexa e mafai ona suʻesuʻeina le faʻamaʻi o le Alzheimer.
O lo'o fusifusia le Dihexa i le maualuga o le HGF ma le dihexa uma ma lona matua fa'atasi Norleucine 1-AngIV fa'aosoina le c-Met phosphorylation i le i ai o fa'atonuga o le HGF ma fa'ateleina le fa'asalalauina o le cell HGF.E le gata i lea, o le dihexa ma le Nle1-AngIV faʻaosoina le spinogenesis hippocampal ma le synaptogenesis tutusa ma le HGF lava ia.Dihexa lelei inhibits HGF dimerization i 1 μM. A o dihexa i 1 nM ma 10 pm na o ia e le faagaoioia c-Met, e faailogaina augments le gafatia o le HGF i 1.25 ma 2.5 ng / mL e faagaoioia c-Met.
O le Dihexa e umi lona ta'amilosaga afa-ola.O lo'o fa'aalia e Dihexa le fa'agaioiga.E fa'aleleia ai a'oa'oga fa'avanoa i iole matutua.O le Dihexa e fa'aosoina le spinogenesis i fa'atupuina neu hippocampal.
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