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Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide

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  • Igoa masani:Exendin-4
  • Numera CAS:141758-74-9
  • fua mole:C184H282N50O60S
  • mamafa mole:4186.57188
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    uiga:

    Igoa masani Exenatide igoa faaperetania Exenatide acetate masima
    Numera CAS 141758-74-9
    fua mole C184H282N50O60S
    mamafa mole 4186.57000
    Massa sa'o 4184.03000
    PSA 1775.05000
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    Maumau Leai se pala, leai ni fa'alavelave mata'utia e iloa pe a fa'aoga ma teuina e tusa ai ma fa'amatalaga

     

    Fa'aoga:

    O le Exenatide o le vailaʻau muamua lea i se vasega fou o le anti-diabetics ua taʻua o le incretin mimetics, ma ua faʻaalia o se togafitiga faʻaopoopo e faʻaleleia ai le pulea o le glycemic i tagata mamaʻi e maua i le maʻisuka ituaiga 2 o loʻo faʻaaogaina le metformin, sulfonylurea, poʻo mea uma e lua, ae leai. maua le pulea lelei o le glycemic.O le Exenatide o se faʻataʻitaʻiga galue o le tagata incretin Glucagon-Like Peptide-1 (GLP-1).O le GLP-1 e masani lava ona fa'asa'oloto mai sela i totonu o le GI tract e tali atu i mea'ai ma galue i luga o lona tali i luga o sela-b e fa'amalosia ai le fa'aosoina o le inisalini e fa'aosoina le kulukose.O le Exenatide o se agonist umi e galue i le GLP-1 tali.Ose mea fa'akomepiuta ole 39-amino acid peptide o lo'o maua ile salivary lizard ole Gila monster lizard.fa'apena fo'i ona fa'atama'ia le maualuga ole glucagon ile toto ile taimi ole hyperglycemic pe a mae'a taumafataga, ae e le fa'alavelaveina le tu'uina atu o le glucagon e tali atu i le hypoglycemia.Ole fa'atonuga ole tui ole exenatide ole 5 po'o le 10 mg fa'alua i aso ta'itasi, fa'atinoina e pei o se tui i lalo o le pa'u i totonu ole itula a'o lumana'i taumafataga o le taeao ma le afiafi.I le maeʻa ai o le faʻaogaina o le subcutaneous, o le maualuga o le plasma concentration o le exenatide e oʻo i le 2.1 itula, ma o le plasma pharmacokinetic profile e faʻatusatusa fua.O fa'alavelave fa'alavelave e masani ona lipotia mai i le exenatide e aofia ai le fa'afuiu, pua'i, manava manava, lagona le mautonu, niniva, ulu tiga, ma le dyspepsia.

    E mafai e le Exendin-4 ona faʻagaoioia le GLP-1 tali, e mafai e le faʻafeiloaʻi ona faʻateleina le maualuga o le cAMP o sela acinar pancreatic i totonu o le intracellular, ae leai se aʻafiaga i le VIP receptor.

    Exendin-4 ua faʻaaogaina e fai ma faʻataʻitaʻiga incretin mo togafitiga i sela HepG2 e le aofia ai le aʻafiaga o mea fesoasoani.Ua fa'aaogaina fo'i e fai ma agonist r (GLP-1R) e fa'aesea ai fa'alavelave mai mea fa'aausilali.

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