Agonist API GW501516 pa'epa'e pa'epa'e
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Fa'aoga
GW 501516 o se agonist o PPARδ ma le EC50 tau o le 1.1 nM.
GW501516 o loʻo faʻaalia o le PPARα agonists sili ona malosi ma filifilia e iloa ma le EC 50 o le 1. 1 nM e faasaga i le PPARα ma le 1000-fold selectivity i luga o isi subtypes tagata, PPARα ma -γ.GW501516 o lo'o fa'aolaina a'afiaga fa'ama'i i totonu o sela fa'alatalata fa'alatalata (mProx) fa'aa'e i isumu.GW501516 fa'asaina le palmitate- ma le TNFα-faʻateleina faʻateleina i le MCP-1 mRNA faʻamatalaga i se fua faʻalagolago.
O le GW501516 e mafua ai le faʻaleagaina o ponaivi, e mafua ai le faʻaitiitia o le BMD ma le faʻaleagaina o meatotino o ponaivi i isumu OVX.GW501516 fa'ato'ilaloina fa'ama'i fa'alatalata ma fa'aleagaina sela tubular i totonu o se fa'ata'ita'iga nephropathy o le kiore o le polotini.GW501516 togafitiga faʻaleleia le taʻavale tumau ma le vaega o succinate dehydrogenase (SDH) -alava maso lelei i isumu aʻoaʻoina ma le le aʻoaʻoina.
Fa'amatalaga
Igoa masani | GW-501516 | igoa faaperetania | GW501516 |
Numera CAS | 317318-70-0 | mamafa mole | 453.498 |
mafiafia | 1.4±0.1 g/cm3 | mea fa'apuna | 584.5±60.0 °C ile 760 mmHg |
fua mole mole | C21H18F3NO3S2 | mea liusuavai | 134-136°C |
PSA | 112.96000 | mea moli | 307.3±32.9 °C |