Sarm S4 Andarine Samasama pauta
Fa'afeso'ota'i a'u
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Fa'aoga
Andarine (S-4) o le arilpropionamide-e maua mai le tuufaatasiga [S-3-(4-acetylamino-phenoxy) -2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl) -propionamide] muamua faamatalaina e Yin et al.ia avea ma se filifili faʻaogaina o le androgen receptor modulator (SARM).Andarine (S-4) na faʻaalia e in vitro ma in vivo suʻesuʻega e avea o se agonist anabolic aoga, e aunoa ma ni aʻafiaga e masani ona fesoʻotaʻi ma anabolic-androgenic steroids, e faʻatatau i le mea e faʻaogaina ai le substrate mo le 5α-reductase e maua ai le DHT i le prostate.
O le gaioiga faʻafomaʻi o le andarine o loʻo fautua mai ai le tele o le malosi o le andarine i le atinaʻeina o SARM o loʻo maua ile falemaʻi, lea e ofoina atu ai faʻamanuiaga faʻapitoa faʻapitoa i luga o latou vailaʻau faʻamaʻi ma se avanoa fiafia e faʻaeseese ai le faʻatonutonuina o aʻafiaga o le androgen i le tele o gaʻo, ma faʻaitiitia ai le faʻalavelave i le masani. .O le mea lea, o loʻo faʻamaonia e le andarine i suʻesuʻega faʻapitoa faʻapitoa e faʻamoemoe e togafitia faʻamaʻi e fesoʻotaʻi ma tausaga ma faʻafefe ai faʻamaoniga o faʻamaʻi ogaoga e pei o le sarcopenia ma le kanesa cachexia.
O le Andarine o se fa'ama'i fa'ama'i e le fa'aogaina ole androgen (AR) fa'atasi ma le Ki o le 4 nM.Andarine o loʻo faʻaalia le malosi ma le malosi o le anabolic ma e mafua ai le faʻamalosia o le faʻatupulaia o le prostate, seminal vesicle, i le faasologa.O le Andarine e iai ni mea fa'aantiosteoporotic.
Andarine (lea sa taʻua muamua o GTx-007; S-4; GTx007; S4) o se agonist e le o ni steroidal androgen receptor (AR), faʻapitoa i le faʻaogaina o le androgen receptor modulator (SARM), e mafai ona aoga i le faʻaumatia maso. ma le osteoporosis.E fa'agaoioia le AR ma le Ki o le 4 nM ma e filifili-filifili mo totoga anabolic.Andarine o loʻo suʻesuʻeina mo le togafitia o tulaga e pei ole faʻamaʻi maso, osteoporosis ma le prostatic hypertrophy.I se faʻataʻitaʻiga manu o le hypertrophy prostatic benign, na faʻaalia e le andarine le faʻaitiitia o le mamafa o le prostate ma le aoga tutusa i le finasteride, ae aunoa ma le faʻaitiitia o le maso maso poʻo le anti-androgenic aʻafiaga.
Fa'amatalaga
igoa masani | SARM S4 | igoa faaperetania | Andarine |
Numera CAS | 401900-40-1 | mamafa mole | 441.358 |
mafiafia | 1.5±0.1g/cm3 | mea fa'apuna | 698.7±55.0 °C ile 760 mmHg |
fua mole mole | C 19 T 18 F 3 N 3 O 6 | mea liusuavai | 70-74ºC |
PSA | 133.48000 | Fa'ailoga moli | 376.4±31.5 °C |
LogP | 4.01 | mamafa ausa | 0.0±2.3mmHg ile 25°C |