Tesamorelin CAS: 804475-66-9 Unii-mqg94m5eeo Th 9507
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Ikoreshwa
Tesamorelin (INN) (izina ry'ubucuruzi Egrifta SV) ni uburyo bwogukora imisemburo ikura irekura imisemburo (GHRH) yo kuvura lipodystrofiya iterwa na virusi itera sida kandi byemewe mu mwaka wa 2010. Yakozwe kandi itezwa imbere na Theratechnologies, Inc. Kanada.Uyu muti ni peptide ya sintetike igizwe na acide 44 zose za amino ya GHRH yumuntu wongeyeho itsinda rya acide trans-3-hexenoic
Uburyo bwibikorwa
Tesamorelin ni N-terminus yahinduwe igizwe na 44 amine acide ikurikirana ya GHRH.Ubu buryo bwahinduwe bwubukorikori burakora neza kandi buhamye kuruta peptide karemano.Irwanya kandi clavage na dipeptide aminopeptidase kuruta GHRH yabantu.Itera synthesis ya endogenous GH ikarekura kandi ikongera urwego rwibintu bisa na insuline (IGF-1).GH yasohotse noneho ihuza reseptors igaragara kumubiri itandukanye kandi ikagenga imiterere yumubiri.Aya mabwiriza ahanini aterwa no guhuza uburyo bwa anabolike na lipolysis.Nyamara, uburyo nyamukuru bwifashishijwe tesamoline bwagabanije ibinure byumubiri ni ukugabanya urugero rwa triglyceride nyuma ya lipolysis.