Teduglutide CAS: 197922-42-2 Teduglutide (ALX-0600) Revestive

Igikorwa:
Teduglutide, izwi mu Cyongereza nka Teduglutide, ni analogue ya glucagon imeze nka peptide 2 (GLP-2), imisemburo isanzwe ibaho igabanya gusohora igifu no gusohora kandi ikagenga imikurire, ikwirakwizwa, no gusana ingirabuzimafatizo zo mu nda.Umuti wongera umubare w'utugingo ngengabuzima, wongera kwinjirira mu mara mato no kugabanya impiswi.
Imyiteguro:
Imiterere yimpeta zigizwe nabantu batanu zifitanye isano cyane na aside amine iburyo ya Asp cyangwa Asn, kandi Gly nuburyo bworoshye bwimpeta iyo Gly ihujwe mbere ya Asp kubera kubura itsinda ririnda hamwe nimbogamizi nke za steric kuruhande urunigi.Kubwibyo, byanze bikunze uburyo bwo guhuza uburyo buzakora N-terminal amino acide ya Tedulu Chemical Book peptide ikora impeta yabanyamuryango batanu mugikorwa cya synthesis, bizagabanya ubuziranenge.Kubwibyo, kugirango dukemure ikibazo cyo gutesha agaciro igice cya Asp-Gly, igice kirinzwe rwose hamwe nimiterere yerekanwe muri SEQIDNO: 2 cyabanje guhuzwa no guhuza ibice.Igice cyarinzwe rwose ni aside ya mbere ~ ya kane ya amino acide ya N-terminal ya tidulutide, harimo imiterere ya Asp-Gly, hanyuma igice kirinzwe cyuzuye cyezwa.Igice gisukuwe neza cyarinzwe neza cyari icyiciro gikomeye gifatanije nigice cya peptide resin hamwe nuburyo bwerekanwe muri SEQIDNO: 12, hanyuma clavage yanyuma ikorwa kugirango tidurotide.