SARM SR9011 Ifu yimiti ya farumasi yo kongera imyitozo yo kwihangana CAS 1379686-30-2
SR9011 Ibisobanuro byihuse
Cas No 1379686-29-9
Synonyme 3 - (((4-chlorobenzyl) ((5-nitrothiophen-2-yl) methyl) amino) methyl) -N-pentylpyrrolidine-
1-carboxamide
Inzira C23H31ClN4O3S
Uburemere bwa Molucelar 479.03524
SR9011Ibisobanuro
SR9011 ni methacrylate monomer itanga imikorere itanga ibyuma bidasanzwe
substrates.
SR9011 irasabwa gukoreshwa muri peroxide ikize, ikidodo, hamwe na plastisol ishingiye kuri PVC.
Urwego rwo gukoresha rwa 5% kugeza 10% kuburemere birasabwa.
SR9011 nimbaraga zikomeye kandi zihariye REV-ERB.Ifite kandi ibyiza muri vivo plasma / ubwonko.
Ibyakirwa na kirimbuzi REV-ERB-α na REV-ERB-β bigira uruhare runini mugutunganya imvugo
ya poroteyine yibanze yisaha, gutwara injyana mubikorwa na metabolism.Ubuyobozi bwa SR9011
Imyitwarire ya circadian hamwe na circadian yerekana isaha yibanze ya gene imvugo muri hypothalami yimbeba.
Imvugo ya circadian yerekana imiterere ya genes metabolike yumwijima, imitsi ya skeletale na
adipose tissue nayo yarahinduwe, bituma ingufu zikoreshwa.Umuti uterwa nimirire
imbeba zifite umubyibuho ukabije hamwe na SR9011 zagabanije umubyibuho ukabije mu kugabanya ibinure kandi byateye imbere cyane dyslipidaemia na hyperglycaemia.Ibisubizo byerekana ko sintetike REV-ERB ligands igamije imiti
injyana ya circadian irashobora kuba ingirakamaro mukuvura indwara zidasinzira kimwe nindwara ziterwa na metabolike.
Nigute ushobora gukoresha SR9011?
Muri vitro: SR9011 yakoreshejwe kuri 5-10 μM yibanze muri vitro no muri selile.
Muri vivo: Ubuyobozi bwa IP bwa SR9011 bwakoreshejwe 100 mg / kg rimwe cyangwa kabiri kumunsi kuri 12-30
iminsi muburyo butandukanye bwimbeba.
Synthesis ya SR9009 na SR9011
| Ingingo | Ibisobanuro | Igisubizo |
| Kugaragara | Impumuro nziza, ifu yera cyangwa yera | pass |
| Indangamuntu | Igihe cyo kugumana impinga nkuru ni kwemeza RS | pass |
| Gutakaza Kuma | Ntabwo arenze 0.5% | 0.33% |
| Suzuma (HPLC) | Ntabwo ari munsi ya 99.0% | 99.59% |
| Igisigisigi | Ntabwo arenze 0.1% | pass |
| Icyuma kiremereye | Ntabwo arenze 20 ppm | pass |
Gupakira & Gutanga
