Gukura kwa Osteogenic Peptide-OGP CAS: 132996-61-3 OGP acetate OSTEOGENIC GUKURIKIRA PEPTIDE USP / EP / BP

Somatostatin, izwi kandi ku izina rya hormone suppressor hormone (GHIH) cyangwa andi mazina menshi, ni imisemburo ya peptide igenga sisitemu ya endocrine kandi ikagira ingaruka ku ikwirakwizwa rya neurotransmission no gukwirakwizwa kw ingirabuzimafatizo zikorana na G-protein zifatanije na reseptor ya somatostatine kandi ikabuza kurekura ibintu bitandukanye. imisemburo.Imisemburo ya kabiri.Somatostatin ibuza insuline na glucagon gusohora.

Somatostatin ije muburyo bubiri bukora, ikorwa no guhinduranya guhinduranya progenine imwe: imwe igizwe na aside amine 14 (yerekanwa mumasanduku yamakuru iburyo), indi igizwe na acide 28 amine.

Muri nyababyeyi, hari genes esheshatu zitandukanye za somatostatine, yitwa SS1, SS2, SS3, SS4, SS5, na SS6.Zebrafish ifite zose uko ari esheshatu.Ingirabuzimafatizo esheshatu zitandukanye, hamwe na reseptor eshanu zitandukanye zakira, zitanga somatostatine ibikorwa byinshi.Abantu bafite gene imwe ya somatostatine, SST.

sisitemu y'ibiryo
Somatostatine isohorwa na selile ya delta ahantu henshi muri sisitemu yigifu, aribyo sinus pyloric sinus, duodenum, nibirwa.

Somatostatin yarekuwe na pyloric sinus yinjira mumutima binyuze muri sisitemu ya portal hanyuma ikinjira mukuzunguruka kwa sisitemu kurubuga rwabujijwe.Mubyongeyeho, somatostatine yarekuwe na δ selile irashobora gukora muburyo bwa paracrine.

Mu gifu, somatostatin ikora mu buryo butaziguye ingirabuzimafatizo zitanga aside ikoresheje reseptor ya G-proteyine ihujwe na reseptor (ibuza adenylate cyclase bityo ikarwanya neza imbaraga za gistamine) kugirango igabanye aside aside.Somatostatine kandi idindiza neza uburyo bwigifu igabanya mu buryo butaziguye umusaruro wa aside igifu mu guhagarika irekurwa ry’indi misemburo nka gastrine na histamine.