Ingingo yo kurwanya gusaza yarushijeho kumenyekana mu myaka yashize, hamwe n’ubushakashatsi butandukanye bwagaragaye mu buryo budashira.
Buri gihe, itsinda ryubushakashatsi rivumbura ibintu birwanya gusaza byadufasha kubaho imyaka ijana.
Twebwe abantu dufite igihe ntarengwa cyo kubaho cyimyaka 150, kubera ko telomereri igabanya gato buri myaka ibiri cyangwa itatu, kandi selile zirashobora kugabana inshuro zigera kuri 50, nkuko Hafrick wo muri Theorome Theory abivuga.
Hariho kandi abahanga bafite ibyiringiro bavuga: umuntu wambere wabayeho kugeza kumyaka 1000, yavutse, kwisi yacu, ashobora kuba wowe oh.
Hamwe niterambere ryibinyabuzima bya biomolecular, dushobora umunsi umwe kuvumbura ibintu byubumaji bizadufasha kuramba.
Noneho, ubeho neza, kora cyane kugirango ubone amafaranga, kandi utegereze tekinoroji ikuze umunsi umwe, birashoboka, mubyukuri ushobora kubaho igihe kirekire.
Uyu munsi, ngiye kubagezaho bimwe mubyizerwa birwanya kurwanya gusaza bizwi, kandi urebe kuri bike wabonye.
1. Epitalon
Epitalon ni peptide ya anti-gusaza peptide, ikomoka kumurongo wa amine acide alanine-glutamine-asparagine-glycine, igenga ibikorwa bya telomerase mumubiri kugirango ifashe kugabanya umuvuduko wo gusaza.
Telomeres ni nkingofero zikomeye zirinda ADN.Chromosomes nyinshi mumubiri zifite telomereri kumpande zombi;Igikorwa nyamukuru cya telomerase nugufasha kugumana uburebure bwa telomereri mumubiri.
Indwara zimwe zifitanye isano na telomereri ngufi, biganisha ku gusaza vuba;Epitalon irashobora gukoreshwa mu kuvura indwara zitera gusaza imburagihe, nka syndrome ya Bloom na syndrome ya Werner.
Epitalon ifasha kandi kugabanya ibyago byindwara ziterwa no kubura telomerase, nka diyabete, kubera ko imisemburo ya insuline ihagarikwa no kubura telomerase.
Peptide irashobora kandi kugira ingaruka nziza kubuzima bwumutima kandi irashobora gufasha kwirinda indwara zumutima;Abahanga barimo kwiga ubushobozi bwayo mukuvura ibibyimba.
2: Curcumin
Turmeric ni ibiribwa bikomoka mu Buhinde cyane, kandi curcumin nicyo kintu cyize cyane cyize muri turmeric, gifite anti-inflammatory na antioxidant.
Ubushakashatsi bwerekanye ko curcumin ikora sirtuins (deacetylase) na AMPK (protein kinase ikora AMP), ifasha gusaza ingirabuzimafatizo no kuramba.
Byongeye kandi, curcumin yerekanwe kurwanya ibyangiritse no kwagura cyane igihe cyisazi zimbuto, inzoka zinzoka, nimbeba;Irashobora kandi gutinza gutangira indwara ziterwa nimyaka no kugabanya ibimenyetso byindwara ziterwa nimyaka
3: urumogi
Ibintu bifatika byurumogi, bizwi hamwe nkurumogi, ni itsinda ryibintu bya terpenoid fenolike, ibyamamare muri byo ni tetrahydrocannabinol (THC) na urumogi (CBD).
CBD irashobora kurwanya radicals yubusa mu ngirabuzimafatizo zuruhu, ikora nka antioxydeant kandi irwanya gusaza.Bikunze kongerwa mubicuruzwa byita kuruhu kandi akenshi bikoreshwa mugukuraho ububabare budashira, hamwe nibisubizo byiza
4: spermidine
Spermidine nikintu gisanzwe cyintanga ngabo, kandi imibiri yacu (yaba igitsina gabo nigitsina gore) itanga hafi kimwe cya gatatu cyayo, ibisigaye biva mumirire yacu.
Inkomoko y'ibiribwa birimo: foromaje ishaje, ibihumyo, natto, urusenda rwatsi, mikorobe y'ingano, kawuseri, broccoli, nibindi.
Abanyaziya bafite aside irike nyinshi mu mirire yabo, ishobora kuba ifitanye isano n'ubuzima bwabo burambye.
Ubushakashatsi kuri spermidine bwagiye bwiyongera mu myaka yashize, kandi byagaragaye ko bufite ingaruka zikurikira:
Ongera ubuzima buzira umuze;
Kunoza urwego rwubwenge rwabasaza;
Ingaruka ya Neuroprotective;
Kugabanya impfu zose zitera;
Umuvuduko ukabije w'amaraso;
Gutera autophagy no gutinda senescence;
Bituma umusatsi ukura vuba kandi imisumari ikomera.
5: umubiri wa ketone
Imwe mumpamvu nyamukuru indyo ya ketogenic ikunzwe ni ugutakaza ibiro no kumvikana mumutwe.
Iyo umubiri utangiye gutwika ibinure byumubiri, ubyara umubiri wa ketone, utanga imbaraga zisukuye mubwonko no kunoza imikorere.
Ketone ifite imiti irwanya gusaza, kandi ubushakashatsi bwerekanye ko BHB (beta-hydroxybutyric aside) ishobora guteza amacakubiri, ikarinda gusaza ingirabuzimafatizo, kandi igakomeza imiyoboro y'amaraso n'ubwonko bukiri muto.
Umubiri urashobora kubyara imibiri ya keto wirinda karubone, cyangwa irashobora gufata inyongera ya keto kugirango yihutishe inzira kandi igabanye ububabare bwinzibacyuho, izwi nka "ibicurane bya keto."
Indyo ya Ketogenic, cyangwa gufata inyongera ya keto yinyongera, irashobora gutinda gusaza, kunoza imikorere yubwenge, no gufasha kwirinda indwara zifata ubwonko nka Alzheimer.
6: Dasatinib
Mugihe tugenda dusaza, zimwe mungirabuzimafatizo zacu zirinda sisitemu yumubiri.Izi selile "zirokoka" ntizikora ibyo zagombaga gukora, ariko ziracyatwika ingufu.
Ingirabuzimafatizo nkizo "ibiryo byose kandi nta kazi", bizwi kandi nka "zombie selile", cyangwa selile senescent, zegeranya igihe, bigatuma umubiri ukora neza.
Kwiyiriza ubusa, gukora siporo nubundi buryo bwiza bwo kubaho butera autophagy, isukura selile zombie.
Dasatinib, imiti ya chimiotherapie ikoreshwa mu kuvura indwara ya leukemia, irashobora kandi kuvanaho neza ingirabuzimafatizo zishaje kandi bikagabanya ururenda rwa cytokine itera indwara mu mubiri wa adipose y'umubiri.
Nibiyobyabwenge bya mbere bya Senolytics byavumbuwe, ibiyobyabwenge bihanagura neza ingirabuzimafatizo za senescent bivanga na selile ya senescent yerekana inzira, bigahagarika by'agateganyo SCaps (inzira irwanya apoptotique).
Ibintu bishobora gukuraho ingirabuzimafatizo zirimo PCC1 mu Ishuri Rikuru ry'Ubushinwa, kimwe n'ibindi bintu nka quercetin.
Igihe cyo kohereza: Gashyantare-24-2023