Clobetasol propionate irashobora kuvurwa na psoriasis? Indwara zose zuruhu zisanzwe?

Clobetasolirashobora kuvurwa psoriasis.

Synonyme:

17; CLOBETASOL 17-YAKORESHEJWE USP; [(8S, 9R, 10S, 11S, 13S, 14S, 16S, 17R) -17- -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta [a] phenanthren-17-yl] propanoate; Dermovate

Ikoreshwa:

Clobetasol Yamamazani umunyu wa propionate ya clobetasol, corticosteroid ya syntetique yibanze hamwe na anti-inflammatory, anti-pruritis, na vasoconstrictive.Clobetasol propionate igira ingaruka zayo muguhuza reseptor ya cytoplasme glucocorticoid hanyuma igakora glucocorticoid reseptor ihuza imvugo ya gene.Ibi bivamo synthesis ya proteine ​​zimwe na zimwe zirwanya inflammatory, mugihe zibuza guhuza abunzi bamwe na bamwe.By'umwihariko, clobetasol propionate isa nkaho itera poroteyine ya fosifolipase A2, bityo ikagenzura irekurwa rya acide prursor arachidonic acide ya membrane fosifolipide na fosifolipase A2.

Clobetasol propionate ni 17-O-propionate ester ya clobetasol kandi ikomoka kuri clobetasol na aside protionique.Corticosteroid ikomeye, ikoreshwa mukuvura indwara zitandukanye zuruhu, harimo exzema na psoriasis.
Clobetasol propionate yatanzwe mu 1968 itangira gukoreshwa mu 1978. Iraboneka nk'imiti rusange.Clobetasol propionate ikoreshwa mukuvura indwara zitandukanye zuruhu zirimo eczema, herpes labialis, psoriasis, na lichen sclerosus.Ikoreshwa kandi mu kuvura indwara nyinshi ziterwa na auto-immune, harimo alopecia areata, lichen planus (auto immune skin nodules), na mycose fungoides (T-selile lymphoma).Ikoreshwa nkumurongo wambere wokuvura GVHD ikaze kandi idakira yuruhu.Clobetasol propionate (Cormax, Temovate, Embeline, Olux) nimwe mumbaraga zikomeye mubikoresho biriho ubu kandi byerekanwe kuvura mugihe gito cyo kuvura indwara cyangwa hyperplastic disorders.Nibikoresho bya fluorine corticosteroid.Irashobora gutera igisubizo cyihuse cyangwa kirekire kurenza izindi corticosteroide yibanze.Birasabwa ko clobetasol ifite progaramu ntarengwa ya 60 g / icyumweru mugihe kitarenze iminsi 14 nta gufunga kandi ko idakwiye gukoreshwa mubana bari munsi yimyaka 12.

Umuti wa betamethasone 21-methanesulfonate (4 g) muri dimethylformamide (ml 25) wavuwe na lithium chloride (4 g) hamwe nuruvange rushyushye ku bwogero bwamazi muminota 30.Kuvomera amazi byatanze ibicuruzwa bitavanze byongeye gushyirwaho kugirango bishyure umutwe, MP 226 ° C.
Ubusanzwe Clobetasol ihindurwamo propionate nkuburyo bwingirakamaro mugukora hamwe na anhydride ya propionic.