CAS: 38304-91-5 Minoxidil alostil lonolox

Intangiriro

Minoxidil, izwi kandi nk'umuvuduko ukabije w'idine, Minoxidil, amata ya molekile hamwe n'uburemere bwa molekuline ugereranije C9H15N5O = 209.25, ni ifu yera cyangwa yera ya kirisiti ya kirisiti, ishonga gato mumazi cyangwa chloroform, ikabura gato muri Ethanol, igashonga gato muri acetone, igashonga muri acide acike.Irashobora gukora neza kurukuta rwamaraso, kwagura arterioles, kugabanya kurwanya periferique, kugabanya umuvuduko wamaraso, no kongera umuvuduko wumutima hamwe numutima.Nyamara, anti-hypertensive ingaruka zayo zirahambaye kandi ziramba kuruta hydrazine.

Ingaruka ya farumasi

Minoxidil yagura arterioles mu buryo butaziguye, bityo igabanya umuvuduko wamaraso, ariko uburyo nyabwo ntiburamenyekana.Ibicuruzwa ntabwo byagura imiyoboro.Kugabanuka kwimitsi iva mumitsi itera umuvuduko ukabije wumutima no kongera umutima.Ibikorwa bya Renin byiyongera nyuma ya hypotension, bikaviramo amazi na sodium.Iki gicuruzwa ntikibangamira moteri yimitsi yimitsi Chemical reflex, bityo hypotension ya orthostatike ntabwo ibaho.Minoxidil niwo muti ukunze gukoreshwa kandi ufite akamaro mu kuvura umusatsi, ariko ingaruka za farumasi n'ingirabuzimafatizo zawo ntusobanutse neza.Mu myaka yashize, ubushakashatsi bwerekanye ko Minoxidil ishobora guteza imbere imisatsi binyuze muburyo bukurikira.

Umuti wo mu kanwa wakoreshejwe mubuvuzi kugirango ugabanye umuvuduko wamaraso

Minoxidil ni ubwoko bw'imiti yo mu kanwa ikoreshwa mu kugabanya umuvuduko w'amaraso mu mavuriro, izwi kandi nka Changbaridine, piperazine enediamine, hypotenidine na Minlohemoidine.Nibintu bifungura umuyoboro wa potasiyumu, ushobora koroshya imitsi yoroshye yimitsi kandi ikagira ingaruka zikomeye zo kwaguka kwimitsi, kugabanya kurwanya periferique, kwaguka kwamaraso hamwe numuvuduko wamaraso, ariko ntigire ingaruka kumitsi, bityo irashobora guteza imbere kugaruka kwimitsi.Muri icyo gihe, umutima uva hamwe n'umuvuduko w'umutima birashobora kwiyongera bitewe na reflex igenga n'ingaruka nziza, ariko ntibitera hypotension ya posita.Ivuriro rikoreshwa mukuvura hypertension yangiritse na hypertension yimpyiko.Irashobora kandi gukoreshwa muri hypertension ikabije hamwe no kutakira neza indi miti igabanya ubukana, ariko igomba guhuzwa na diuretique kugirango wirinde amazi na sodium.Iyo uhujwe na β-guhagarika imiti, imikorere yayo irashobora kwiyongera kandi ingaruka mbi zikagabanuka.Ingaruka imwe yo gukoresha igihe kirekire gukoresha Minoxidil na Chemical ni uko umusatsi wumubiri ushobora kwiyongera gato hamwe no gukomeza gukoresha ibiyobyabwenge, nkumusatsi wamaboko.Ariko muri rusange mubipimo byemewe.Ingaruka nyamukuru ziterwa nubuyobozi bwo mu kanwa zirimo kwiyongera ibiro hamwe no kuribwa mu maguru biterwa no kugumana amazi na sodium, palpitation na arththmia biterwa na reflex sympathetic nervice nervice, na hirsuism.Ingaruka nyamukuru ziterwa nimyiteguro yibanze ni kurwara uruhu, erythema, pruritus nizindi ngaruka za dermatite.Nubwo ingano yo kwinjizwa mu myiteguro y’ibanze ari nto cyane, ntidushobora guhakana ko ishobora kugira ingaruka ku miterere y’abarwayi bafite amateka y’indwara z'umutima.Abarwayi bafite indwara zifata ubwonko, kunanirwa k'umutima bidatewe na hypertension, indwara z'umutima zifata umutima, angina pectoris, infarction myocardial, pericardial effusion, imikorere mibi yimpyiko nizindi ndwara bagomba gukoreshwa neza, allergie ya minoxidil hamwe naba barwayi ba pheochromocytoma bagomba kwanduzwa