Ibimera bisanzwe bikuramo CAS 51-34-3 Scopolamine

Scopolamine(hyoscine) iboneka mubintu bitandukanye bya Solanaceae (urugero, H. niger, Duboisia myoporoides, Scopolia spp., na Datura metel).Scopolamineus isanzwe yitandukanije n'inzoga za nyina zisigaye ziterwa na hyoscyamine.

Hyoscine nizina rya kera ryiyi alkaloide, nubwoscopolamine nizina ryemewe muri Reta zunzubumwe zamerika.Scopolamine nigice cya levo kigizwe nuruvange rwamoko ruzwi nka atroscine.Alkaloide ivangura amoko byoroshye kuboneka kwa alkali.

Alkaloide ibaho muburyo bwa levorotatory, viscousliquid ibora gusa mumazi ariko inzoga zishushe cyane, chloroform, cyangwa ether.Ikora umunyu wa kristalline hamwe na acide nyinshi, hamwe na hydrobromide niyo ihagaze neza kandi yemerwa cyane.Igisubizo cyamazi ya hydrobromide irimo 10% mannitol bivugwa ko idakunda kubora kuruta ibisubizo bidakingiwe.

Imiti

Scopolamine butylbromide, scopolamine yahinduwe, ni imiti igabanya ubukana bwa choline;ntishobora gusa kunanura imitsi gusa ahubwo irashobora no guhagarika ganglion na neuromuscular ihuza kandi ikagira ingaruka nke kuri centre.Uyu muti ugira ingaruka zikomeye kumitsi yoroshye yo munda kuruta atropine na anisodamine;irashobora guhitamo kugabanya inzira zo munda, inzira ya biliary, hamwe ninkari zinkari zorohereza imitsi kandi ikabuza peristaliside.

Scopolamine butylbromide igira ingaruka nke kumutima, umunyeshuri, na glande y'amacandwe, kubwibyo ntibikunze gutera umunezero mwinshi wo hagati, kwaguka, kubuza gusohora amacandwe, nibindi bitekerezo bibi, bitandukanye na atropine.

Scopolamine butylbromide ni antagonist ya reseptor ya M cholinergique, ingaruka za farumasi zisa na atropine, ariko ifite imiterere yayo ifite inyungu zigaragara mugutezimbere microcirculation.