HU-210 URUBANZA OYA: 112830-95-2

HU-210 ni (-) enantiomer ya 11-OH-D 8-THC-DMH, ifite ibikorwa hafi ya byose byurumogi, mugihe enantiomer (+), yitwa HU-211, idakora nkurumogi, ariko ikora ahubwo nk'urumogi nka NMDA antagonist hamwe n'ingaruka za neuroprotective.

HU-210 irashobora guteza imbere ikwirakwizwa, ariko ntigutandukane, ryumusemburo wimitsi ya hippocampal neural stem selile hamwe na selile progenitor ukoresheje reseptor ya CB 1, poroteyine G i / o, na ERK byerekana uko bikurikirana.Uku kwiyongera kw'imitsi kandi kwerekana ko hakenewe ingaruka zo kurwanya amaganya n'ingaruka zo kwiheba.

Hamwe nizindi miti ya urumogi, nka WIN 55,212-2 na JWH-133, HU-210 irinda indwara ziterwa na beta amyloide yatewe n'indwara ya Alzheimer, usibye gukumira ubumuga bwo kutamenya no gutakaza ibimenyetso bya neuronal.Izi ngaruka zo kurwanya inflammatory ziterwa no gukora kwa reseptor ya urumogi, birinda gukora selile ya microglia inflammatory.Byongeye kandi, urumogi rwakuyeho burundu neurotoxicity ijyanye no gukora selile ya microglial selile muburyo bwimbeba.

HU-210 ni imiti igabanya ububabare ifite ingaruka nyinshi zimwe na THC karemano.

Umunwa LD50 wa HU-210 ni 5.000mg / kg mu mbeba na 14,200mg / kg mu nkwavu.LDLO (dose yica cyane) ya HU-210 mubantu ni 143mg / kg.LD50 ya cafeyine ngo ni 150-200 mg / kg.Delta-8-THC LD50 ntabwo byemejwe.Mu bushakashatsi bwakozwe mu 1973, inkende n'imbwa byahawe 9000 mg / kg bya Delta-8-THC ntabwo byica.