GW-0742 Ifu ya SARMs |GW610742 CAS 317318-84-6
Ikoreshwa
Ku mubyibuho ukabije, diyabete, dyslipidemiya n'indwara z'umutima n'imitsi Umuti Umushakashatsi ugamije kurwanya lipide no kongera urwego rwa HDL, cyangwa cholesterol nziza, mu maraso.Ingirabuzimafatizo-yemewe, thiazolyl compound ikora nkibintu bikomeye, bifitanye isano ryinshi, PPARδ agonist.Erekana guhitamo PPARδ ugereranije na PPARα na PPARγ.Ntabwo isohora igikorwa icyo aricyo cyose kirwanya ibindi byuka bya kirimbuzi cyangwa bitari ibyuka bya kirimbuzi.Bivugwa ko byongera cholesterol efflux na ABAC1 imvugo muri macrophage, fibroblast, na selile zo munda.
Cardarine ikoreshwa nabakinnyi bahatanira siporo itandukanye.Kurugero, abakinnyi bihangana barashobora kongera kwihangana kwimyitozo mugushyira iyi PPAR hamwe nibiyobyabwenge bya AMP bigereranya AICAR, cyangwa gukoresha karidine wenyine.Nkigisubizo, bazagira ubushobozi bunini bwo kugera kuri RPM yo hejuru mugihe biruka badakubise umuvuduko ntarengwa wumutima.Ibi bizafasha kwiruka / gusiganwa ku magare / koga gushuka umuvuduko ntarengwa w’umutima kandi ukagenda igihe kirekire utiriwe uhuhuta, bigatuma iyi stack ari intwaro idasanzwe yo gukoresha muri siporo yo kwihangana.Mubyukuri, nkurikije uburambe ku giti cyanjye nshobora kubwira ko karidinari ishobora gukubita amasegonda 30-45 mugihe cya 5K iyo ikoreshejwe iganisha kumarushanwa.
Ibisobanuro
IJAMBO RY'INGENZI: Gutakaza ibinure, kunoza kwihangana, nta ngaruka mbi, byubaka umubiri, gukiza umubyibuho ukabije bifasha kugumana umubyibuho ukabije, byongera imitsi.
Cardarine (GW-501516) yashyizwe mu cyiciro cya SARMS, nyamara mu miterere no mu bisobanuro, ni moderi ya PPAR.Nka moderi ya PPAR, ikora protein kinase ikora AMP kandi igatera glucose gufata mumitsi ya skeletale.GW-501516 ifite ubushobozi bwo guhindura ibibazo bya metabolisme itera aside irike.Bifatwa nk'ubuvuzi bukomeye ku mubyibuho ukabije n'ibindi bijyanye.
GW501516 nizina ryumuti wa Glaxo Wellcome (GW igereranya isosiyete kandi umubare ni uw'ibicuruzwa).Bizwi kandi nka GW-501.516, GW1516, GSK-516).Ni PPARδ reseptor agonist ntabwo yafashwe kurenza ibizamini byubuvuzi.Nkibyo birabujijwe muri siporo.Ihuza ahantu henshi kurutonde, harimo cyane cyane nka "peroxisome Proliferator Active Receptor δ (PPARδ) agoniste (urugero GW501516)".Ariko kandi bizaza munsi ya WADA ifata igice cyose "kitemewe" kigamije guhagarika ibiyobyabwenge bitemewe bikoreshwa nabakinnyi.
GW501516 (izwi kandi ku izina rya GW-501,516, GW1516, GSK-516) ni PPAR & reseptor agonist wavumbuwe ku bufatanye bwa Ligand Pharmaceuticals na GlaxoSmithKline mu myaka ya za 90, yinjiye mu mavuriro nk'umukandida w'ibiyobyabwenge n'indwara z'umutima n'imitsi. , kandi yaratereranywe mu 2007 kubera ko kwipimisha inyamaswa byerekanaga ko imiti yatumye kanseri ikura vuba mu ngingo nyinshi.
Mu 2007 ubushakashatsi bwasohotse bwerekana ko dosiye nyinshi za GW501516 zahawe imbeba zazamuye cyane imikorere yumubiri;iki gikorwa cyaganiriweho cyane mu bitangazamakuru bizwi cyane, kandi biganisha ku isoko ryirabura ku mukandida w’ibiyobyabwenge ndetse no gukoreshwa nabi n’abakinnyi nkumukozi wa doping.
Porogaramu
GW501516 irashobora gukoreshwa nabakinnyi nkimikorere ya ergogeneque yongera ibiyobyabwenge bitagenzurwa nubuyobozi cyangwa byagaragaye nibizamini bisanzwe.Umwe mu bashakashatsi nyamukuru bavuye mu bushakashatsi ku bijyanye no kwihangana kwinshi byatumye akora ikizamini cy’inkari kugira ngo amenye ibiyobyabwenge, maze abigeza kuri Komite mpuzamahanga ya Olempike.
GW itera glucose gufata no gufata imitsi ya skeletale.Itwika ibinure itera aside irike.Irasabwa nk'uburyo bushobora kuvura umubyibuho ukabije kubera ko ari ubushobozi bwo gushonga vuba amavuta.Nanone, Cardarine yongerera HDL ku kigereranyo cya 79% (cholesterol nziza) no kugabanya LDL (cholesterol mbi) mu bigeragezo by'icyiciro cya kabiri.GW 501516 ni PPARδ agonist.Ibi bifasha kongera urwego rwa HDL uhereye kumagambo yongerewe yerekana cholesterol itwara ABCA1.
GW itera glucose gufata no gufata imitsi ya skeletale.Itwika ibinure itera aside irike.Irasabwa nk'uburyo bushobora kuvura umubyibuho ukabije kubera ko ari ubushobozi bwo gushonga vuba amavuta.Nanone, Cardarine yongerera HDL ku kigereranyo cya 79% (cholesterol nziza) no kugabanya LDL (cholesterol mbi) mu bigeragezo by'icyiciro cya kabiri.GW 501516 ni PPARδ agonist.Ibi bifasha kongera urwego rwa HDL uhereye kumagambo yongerewe yerekana cholesterol itwara ABCA1.
Gupakira & Gutanga
