Glucagon CAS: 16941-32-5 Glucagon (1-29) Umuntu HCl GLUCAGON 1-37

Glucagon, izwi kandi nka hyperglycemin na glucagon, ni imisemburo igororotse ya polypeptide imisemburo isohorwa na α selile zo mu kirwa cya pancreatic, irimo aside amine 29.Imiterere ya molekuline hamwe nuburemere bwa molekuline ugereranije ni C153H225N43O49S = 3482.8.Iyi misemburo yashizwe mu gihugu cyanjye.Ifu yera ya kristaline nziza yubushyuhe bwicyumba, impumuro nziza, uburyohe.Kudashonga mumazi hamwe ninshi mumashanyarazi, gushonga muri acide acide na lyute lye.Imyiteguro myinshi ikozwe muri hydrochloride yayo, ibora mumazi.Ubu birazwi ko glucagon igomba kugumana ubunyangamugayo bwayo kugirango ikore ibikorwa byayo.Imiterere ya hyperglycemic irashobora kuba ihamye mubantu ninyamabere (inkwavu, inka, ingurube, imbeba, nibindi), ariko bitandukanye cyane ninyoni.Numusemburo wingenzi kugirango ugumane isukari isanzwe yamaraso.Igikorwa cyacyo nyamukuru nugukora fosifori muri myocardium, guteza imbere glycogene no kubora nka catecholamine.Kubwibyo, igira ingaruka zikomeye z'umutima kumutima, byongera umuvuduko wumutima, kwandura myocardial no gutembera kwamaraso.Indwara ya Cardioenhancement ntabwo iherekejwe no kwiyongera k'umutima, ahubwo yongerera calcium ion muri cardiomyocytes kandi irashobora gukora adenosine cyclase kuri selile y'umwijima muri membrane ya Chemical, igateza imbere synthesis ya cyclic adenosine fosifate mu ngirabuzimafatizo.Glucagon yavuzwe ko igira ingaruka mubihe bimwe na bimwe byo kunanirwa k'umutima.Byongeye kandi, plasma nayo yiyongereye kuburyo butandukanye muri diyabete, indwara zumwijima, indwara zimpyiko, ikibyimba cya glucagon na stress.Glucagon ifite imikorere ine yumubiri yo guteza imbere umwijima glycogenolysis, umwijima glycogenogenez, lipolysis na ketone umubiri.Irashobora guteza imbere gufata aside amine mu ngirangingo z'umwijima, kwihutisha uburyo bwo kwanduza aside amine mu mwijima, kugabanya ubukana bwa aside amine muri plasma, kugabanya intungamubiri za poroteyine no guteza umwijima glycogenogenez.Byongeye kandi, irashobora kandi gukora ubushobozi bwa lipase yingirabuzimafatizo zo kubika umwijima, kongera irekurwa rya aside irike yubusa, kwihutisha uburyo bwa okiside ya lipoic aside ya selile yumwijima, no kongera umusaruro wumwijima glycoconeogenezi numubiri wa ketone.Muri icyo gihe, glucagon irashobora guhagarika impagarara na peristalisite yo mu gifu, amara mato na colon, kugabanya ubukana bwa gallbladder, kubuza pancreatic exocrine, no kubuza kwinjiza amazi n'umunyu na mucosa yo munda.Umubare munini wa glucagon urashobora kandi kongera ubukana bwa cAMP muri selile myocardial, kongera umuvuduko wumutima no kongera indwara ya myocardial