Ubushinwa Bugurisha CAS 2160555-52-0 5CAKB48 urumogi imbaraga zera
Imiterere yimiti
Synonyme
5CAKB48;
5CI-ADB-A;
5CI-ADB-Ifu;
1H-Indazole-3-carboxamide, 1- (5-chloropentyl) -N-tricyclo [3.3.1.13,7] dec-1-yl-
Ubuhanga
5F-AKB48, cyangwa N- (adamantan-1-yl) -1- (5-fluoropentyl) -1H-indazole-3-carboxamide, ni indazolecarboxamide ya syntetique kuko irimo itsinda rya indazole ryasimbuwe.Iyi indazole moeity isimburwa kuri R1 numuyoboro wa fluoropentyl, gusimburwa gusangirwa na 5F-PB-22.Byongeye kandi, indazole isimburwa kuri R3 hamwe nitsinda rya carboxamide.Iri tsinda rya carboxamide ni N-isimburwa kuri terminal yayo amine hamwe nitsinda rya adamantane.Iri tsinda rigizwe nimpeta enye za cyclohexane zahujwe muburyo budasanzwe bwitwa diamondoid.5F-AKB48 nikigereranyo cya STS-135 aho imiterere ya indole yibanze isimbuzwa base ya indazole.
Ingaruka z'umubiri
Ibyiyumvo byumubiri
"Umubiri muremure" wa 5F-AKB48 urashobora gusobanurwa nkikintu gikaze, kitameze neza, gikubiyemo ibintu byose, hamwe n’amashanyarazi akwirakwira ku mubiri nyuma yo gufatwa bwa mbere.Igumana igihagararo gihoraho kizamuka vuba nigitangira kandi kigera ku mbibi zacyo iyo impinga igeze mbere yo guhita.
Gutakaza ibinyabiziga -
Iyi ngingo itera guhagarika igice cyangwa giciriritse kugenzura moteri yongerera imbaraga igipimo, ariko gake bivamo kutabasha kugenda no gukora ibikorwa byibanze.
Kongera ubushake bwo kurya
Kimwe nizindi nyinshi z'urumogi, 5F-AKB48 itera kwiyongera kwifunguro, rizwi cyane nka "munchies" mumico ikunzwe y'Abanyamerika n'Ubwongereza.Ubushakashatsi ku mavuriro n’ubushakashatsi bwerekanye ko urumogi rwongera ibiryo no gushishikarira ibiryo.Ibi bikekwa ko biterwa nuburyo endocannabinoide muri hypothalamus ikora reseptor ya cannabinoide ishinzwe kubungabunga ibiryo.
Kubabara
Urumogi rwerekanwe mubuvuzi kugirango rutange ububabare binyuze muri agonism yabakira urumogi CB1na CB2, igera kuri sintetike ya cannabinoid reseptor agonist.
Imyumvire yumucyo wumubiri
Impinduka mu rukuruzi
Umwuma
Ibi bizwi cyane nk "umunwa w ipamba" mumico ikunzwe y'Abanyamerika n'Ubwongereza.
Vasodilation
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