Prostaglandine Ibicuruzwa bya shimi 99% byera API Ibikoresho Lumigan Bimatoprost CAS 155206-00-1 yo kuvura ijisho
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Ikoreshwa
Bimatoprost ni umuti wa prostaglandine wakoreshejwe bwa mbere mu kuvura indwara z'amaso nka glaucoma.Izina ry'ibiyobyabwenge ni Lumigan.Ariko, mugihe cyubuvuzi, umurwayi atunguranye yasanze diameter, uburebure nubucucike bwamaso ye yiyongereye cyane.Nyuma, bimatoprost yakoreshejwe mubigeragezo byamavuriro kubwiza bwamaso.Ingaruka nini ku kubyimba no kubyimba amaso yatumye Lattise itangizwa na sosiyete ikora ibijyanye na Lumegen, Allergan.Uyu muti watangijwe mu Kuboza 2008. Byemejwe na FDA yo muri Amerika, byahindutse ibicuruzwa byumwuga byo kwirabura no kubyimba imisatsi.
Muri Nyakanga 2006, bimatoprost-timolol manate compound eye eye yakozwe na Reta zunzubumwe za Amerika Allergan Co., Ltd. yemejwe n’ikigo cy’imiti cy’ubumwe bw’ibihugu by’Uburayi kubera kugabanya igisubizo ku ikoreshwa rimwe β-ryakira reseptor cyangwa prostaglandine.Umuvuduko ukabije w'amaraso cyangwa hypertension ocular ku barwayi bafite glaucoma ifunguye idakira neza uburyo bwo kuvura.Ibitonyanga byamaso birimo 0.0Chemicalbook3% bimatoprost na 0.5% ya timolol maleate, rimwe kumunsi, irashobora gutanga ivuriro ryingirakamaro cyane yo kugenzura umuvuduko wimitsi, kandi ingaruka ni nziza kuruta iyo bimatoprost yonyine.Matoprost cyangwa timolol maleate.Igeragezwa ry’amavuriro ryemeje ko imiti ifite kwihanganira bihebuje, harimo no kugabanya 40% by’indwara ya ocular hyperemia ugereranije na bimatoprost yonyine.
Mu kuvura glaucoma, irashobora kandi gukoreshwa mumazi yo gukura yijisho, intumbero ni 0.03%
Ibisobanuro
| izina RY'IGICURUZWA | Bimatoprost |
| URUBANZA | 155206-00-1 |
| Ubucucike | 1.1 ± 0.1 g / cm3 |
| Ingingo yo guteka | 629.8 ± 55.0 ° C KURI 760 mmHg |
| Ingingo yo gushonga | 66-68 ° C. |
| Molecular | C25H37NO4 |
| Uburemere bwa molekile | 415.566 |
| Ingingo ya Flash | 334.7 ± 31.5 ° C. |
| Ubwiza Bwuzuye | 415.272247 |
| PSA | 89.79000 |
| Injira | 1.98 |
| Kugaragara | Crystal Solid |
| Umuvuduko w'amazi | 0.0 ± 1,9 mmHg kuri 25 ° C. |
| Ironderero | 1.591 |
| Imiterere yo kubika | 20 ° C. |
Bimatoprost CAS zimwe 155206-00-1 Ubushakashatsi:
Olaparib yagize ingaruka nziza kuri Brca1; p53 yibibyimba byamabere (inshinge 50mg / kg intraperitoneal inshinge kumunsi), ariko ntacyo byagize kuri Ecad ibura HR; ibibyimba byamabere p53.Olaparib ntabwo yari afite uburozi bugabanya imbeba zifite ibibyimba.Olaparib yakoreshejwe mu kuvura ibibyimba ihindagurika rya BRCA, nka kanseri yintanga, kanseri y'ibere, na kanseri ya prostate.Byongeye kandi, Olaparib yabujije ingirabuzimafatizo za ATM zabuze guhitamo, byerekana ko Olaparib ishobora gukoreshwa nk'umuntu ushobora kuvura ibibyimba bya lymphhoide ya ATM.
Olaparib ni inhibitor ya PARP nayo irwanya ihinduka rya BRCA1 cyangwa BRCA2.Olaparib igira ingaruka nke kuri tanki (polymer) enzyme-1, kandi agaciro ka IC50 kararenze ibyo.Olaparib kuri concentration ya 30-100nM ikora kuri selile SW620 kugirango idakora PARP-1.Imirongo ya selile idafite BRCA1 (MDA-MB-463 [1] na HCC1937) irumva cyane Olaparib ugereranije na BRCA1- na BRCA2 imirongo ya selile ihagije (Hs578T, MDA-MB-23, T47D) Olaparib ibuza PARP kandi ikabuza gusana gusana , bivamo sensibilité ikomeye ya selile ya KB2P kuri Olaparib.Igisubizo ni uguhindura imirongo imwe kumeneka kumurongo wikubye kabiri mugihe cyo kwigana ADN, bityo bigakora inzira ya recombination ya BRCA2.
Bimatoprost ni intungamubiri ya prostamide F2α ikomoka, ishobora guhitamo kwigana ingaruka za prostamine ikorwa mu mubiri, ikongera umuvuduko w’umusemburo w’amazi, igabanya ubukana bw’urwenya rw’amazi, kandi ikongera umuyoboro wa trabecular na uveal sclera Bifatwa nk’uko kuba imiti yo kurwanya anti-glaucoma hamwe ningaruka zikomeye zo kugabanya umuvuduko wimitsi.Irakwiriye kuvura glaucoma ifunguye (POAG) cyangwa amaso maremare adafite akamaro nindi miti igabanya umuvuduko wimitsi.Abarwayi ba hypertension (OHT).
Icyitonderwa:
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