Ibicuruzwa byimiti Bromazolam CAS 71368-80-4
Amakuru Yibanze
Inzira ya molekulari: C17H13BrN4
- Ingingo yo gushonga: 272.0-275 ℃
- Ingingo yo guteka: 519.8 ± 60.0 ° C (Biteganijwe)
- ubucucike: 1.54 ± 0.1 g / cm3 (20 ºC 760 Torr)
- pka: 2.37 ± 0.40 (Biteganijwe)
- Inzira ya molekulari: C17H13BrN4
- Uburemere bwa molekuline: 353.21600
- Misa nyayo: 352.03200
- PSA: 43.07000
- LogP: 3.12480
Ikoreshwa
Bromazolam yashyizwe mu rwego rwa benzodiazepine yanditswe bwa mbere mu 1976, ariko ntiyigeze igurishwa.Nyuma yaje kugurishwa nkumuti wabashushanyije, ubanza kumenyekana neza na EMCDDA muri Suwede muri 2016. Ni bromo aho kuba chloro analogue ya alprazolam, kandi ifite ingaruka zisa zo gutuza no guhangayika.Bromazolam isa muburyo bwa benzodiazepine gakondo, harimo alprazolam (gusimbuza chlorine na bromine) na bromazepam (hiyongereyeho impeta ya triazole).Alprazolam na bromazepam ni Gahunda ya IV muri Amerika;bromazolam ntabwo iteganijwe neza.
8-Bromo-1-methyl-6-fenyl-4H-s-triazolo [4,3-a]
Uburyo bwo Gutegura
Bavuwe hamwe na pHLS9 (2 mg protein / mL), 25 μg / mL Alamethicine (UGT reaction ivanze B), 90 mM ya fosifate (pH 7.4), 2,5 mM mg 2+, isocitrate ya mM 2,5, na 0,6 mM kuri 37 ° C NADP +, 0.9 U / mL isocitrate dehydrogenase, 100 U / mL superoxide disutase na 0.1 mM acetyl-CoA.Hanyuma, mM 2,5 mM UDP-glucuronic (UGT reaction ivanze igisubizo A), 40 μM PAPS, 1,2 mM SAM, mM dithiothreitol 1 mM, glutathione 10 mM, na 50 μM clobromazolam cyangwa Bromazolam.
Ibisabwa:50 μM Bromazolam kuri 360min muri 37 ° C.
Porogaramu:Bromazolam metabolite yariyamenyekanyemuri pHLS9.